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Study on the association between the Arg194Trp polymorphism in the XRCC1 gene and the risk of hematological malignancies

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Tumor Biology

Abstract

The association between the Arg194Trp polymorphism in the XRCC1 gene and the risk of hematological malignancies has been extensively investigated. However, the results were inconsistent. The objective of the current study is to investigate the association by meta-analysis. We searched the PubMed, Embase, CNKI, Wanfang, and Weipu databases, covering all studies until Aug. 7, 2013. Statistical analysis was performed by using the RevMan4.2 software and the Stata10.0 software. A total of 20 case–control studies concerning the Arg194Trp polymorphism were indentified from 19 articles. In total analysis, our results suggested that the Arg194Trp polymorphism was not associated with an increased/decreased risk of hematological malignancies (odds ratio (OR) = 1.01, 95 % confidence interval (CI) = 0.85–1.22, P = 0.87 for Arg/Trp+Trp/Trp vs. Arg/Arg). In the subgroup analysis by ethnicity, no significant association was found either among Asians (OR = 1.04, 95 % CI = 0.84–1.29, P = 0.72) or among Europeans (OR = 1.04, 95 % CI = 0.72–1.49, P = 0.83); in the subgroup analyses by cancer types, no significant association was found either among leukemia (OR = 1.10, 95 % CI = 0.89–1.35, P = 0.39) or in lymphoma (OR = 0.83, 95 % CI = 0.57–1.22, P = 0.35). The current meta-analysis indicated that the Arg194Trp polymorphism in the XRCC1 gene might be not a risk factor for hematological malignancies. In the future, more large-scale case–control studies are needed to validate these results.

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Authors and Affiliations

  1. West China Hospital/West China Medical School, Sichuan University, Chengdu, Sichuan, 610041, China

    Lizhi Tang, Tianyuan Xiong, Qingyi Jia, Qing He, Xiang Tong, Yuanling Peng, Jiani Shen, Jiqiao Yang & Yonggang Zhang

  2. The Periodical Press of West China Hospital, Sichuan University, Guoxuexiang 37, Chengdu, Sichuan, 610041, China

    Yonggang Zhang

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  1. Lizhi Tang
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Tang, L., Xiong, T., Jia, Q. et al. Study on the association between the Arg194Trp polymorphism in the XRCC1 gene and the risk of hematological malignancies. Tumor Biol. 35, 3009–3016 (2014). https://doi.org/10.1007/s13277-013-1388-5

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  • DOI: https://doi.org/10.1007/s13277-013-1388-5

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