Tumor Biology

, Volume 35, Issue 3, pp 2787–2793 | Cite as

Prognostic value of vascular endothelial growth factor A expression in gastric cancer: a meta-analysis

Research Article

Abstract

Vascular endothelial growth factor A (VEGF-A) is considered as a prime mediator of angiogenesis and has been implicated in carcinogenesis and metastasis. Various studies examined the relationship between VEGF-A overexpression with the clinical outcome in patients with gastric cancer, but yielded conflicting results. Electronic databases updated to September 2013 were searched to find relevant studies. A meta-analysis was conducted with eligible studies which quantitatively evaluated the relationship between VEGF-A overexpression and survival of patients with gastric cancer. Survival data were aggregated and quantitatively analyzed. We performed a meta-analysis of 20 studies that evaluated the correlation between VEGF-A overexpression and survival in patients with gastric cancer. Combined hazard ratios suggested that VEGF-A overexpression had an unfavorable impact on overall survival (OS) (hazard ratio [HR] = 1.57; 95 % confidence interval [CI], 1.30–1.84) and disease-free survival (DFS) (HR = 1.85; 95 % CI, 1.39–2.32) in patients with gastric cancer. No significant heterogeneity (P = 0.487) was observed among 16 studies for OS and among 7 studies for DFS (P = 0.435). VEGF-A overexpression indicates a poor prognosis for overall survival and disease-free survival in patients with gastric cancer.

Keywords

Vascular endothelial growth factor A Gastric cancer Prognosis Meta-analysis 

Notes

Conflicts of interest

None

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2013

Authors and Affiliations

  1. 1.Jiangsu Province Hospital of Traditional Chinese MedicineNanjing University of Traditional Chinese MedicineNanjingChina
  2. 2.Department of Critical Care Medicine81 Hospital of PLANanjingChina
  3. 3.Encephalopathy Center Southwest 14 Wards, Jiangsu Province Hospital of Traditional Chinese MedicineNanjing University of Traditional Chinese MedicineNanjingChina
  4. 4.Department of Gastroenterology, Zhongda HospitalSoutheast UniversityNanjingChina

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