Tumor Biology

, Volume 35, Issue 3, pp 2769–2776 | Cite as

Lack of association of microvessel density with prognosis of renal cell carcinoma: evidence from meta-analysis

  • Bing Zhang
  • Hong Ji
  • Dongliang Yan
  • Shaoqing Liu
  • Benkang Shi
Research Article

Abstract

To investigate microvessel density (MVD) and its association with prognosis of renal cell carcinoma (RCC) by means of a meta-analysis. We obtained published studies and extracted appropriate data, then did a meta-analysis to estimate the predictive role of MVD by combining estimated effect-size from individual studies. Analyses for overall survival (OS) and cancer-specific survival (CSS) were performed, separately. Subgroup analysis stratified by biomarkers were also performed for studies using CD34, factor VIII-related antigen (F VIII) and others, respectively. A total of 20 studies were included for meta-analyses including nine (four for F VIII, three for CD34, and two for others) for OS and 11 (two for F VIII, seven for CD34 and two for others) for CSS. There was no significance of MVD predicting OS or CSS of RCC. The pooled HR for OS was 0.910 (95 % CI 0.824–1.006; P = 0.065) and CSS was 0.977 (95 % CI: 0.915–1.043; P = 0.487). We failed to observe significant association between MVD and prognosis of RCC. Additional studies are needed to provide more precise evidences to support our results.

Keywords

Renal cell carcinoma Microvessel density Prognostic factors Survival 

Notes

Acknowledgements

We thank all the authors of primary studies that are included in our meta-analyses.

Conflicts of interest

None

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2013

Authors and Affiliations

  • Bing Zhang
    • 1
    • 3
  • Hong Ji
    • 2
  • Dongliang Yan
    • 3
  • Shaoqing Liu
    • 3
  • Benkang Shi
    • 1
  1. 1.Department of Urology, Qilu HospitalShandong UniversityJinanChina
  2. 2.Department of pathologyBinzhou Medical University HospitalBinzhouChina
  3. 3.Department of UrologyBinzhou Medical University HospitalBinzhouChina

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