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Two DNA repair gene polymorphisms on the risk of gastrointestinal cancers: a meta-analysis

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Tumor Biology

Abstract

PARP-1 and MGMT play an important role in the DNA repair system and therefore have been implicated in human carcinogenesis. However, the association between the most studied PARP-1 rs1136410: T > C and MGMT rs12917: C > T polymorphism and risk of gastrointestinal (GI) cancers was reported with inconclusive results. Accordingly, a meta-analysis of 23 published case–control studies was conducted to assess the strength of association using crude odds ratios (ORs) with 95 % confidence intervals (CIs). Overall, the C allele of PARP-1 rs1136410: T > C polymorphism was significantly associated with increased susceptibility of GI cancers (homozygote comparison: OR = 1.43, 95 % CI 1.14–1.81; heterozygote comparison: OR = 1.18, 95 % CI 1.07–1.29; dominant model: OR = 1.23, 95 % CI 1.12–1.35; recessive model: OR = 1.30, 95 % CI 1.04–1.62; allelic comparison: OR = 1.19, 95 % CI 1.07–1.32). In the subgroup analysis, still obvious associations were found in the Asian population, gastric cancer, and high-quality studies. For MGMT rs12917: C > T polymorphism, no obvious associations were found for all genetic models overall. However, in the subgroup analysis, we found that the T allele was significantly associated with reduced colorectal cancer risk for heterozygote (OR = 0.83, 95 % CI 0.70–0.97) and dominant model (OR = 0.84, 95 % CI 0.72–0.98). In conclusion, this meta-analysis suggests that the PARP-1 rs1136410: T > C polymorphism is a susceptibility factor for GI cancers, but the variant allele of MGMT rs12917: C > T polymorphism appears to be a protective factor for colorectal cancer. Large-scale and well-designed case–control studies are necessary to validate the risk identified in the present meta-analysis.

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Acknowledgments

This research was supported by the National Natural Science Foundation of China (no. 81171979).

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Authors and Affiliations

  1. Tumor Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, People’s Republic of China

    Yue Hu, Kang Li, Kai Zhang, Yamei Zheng, Jianxu Li & Li Liu

  2. Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, People’s Republic of China

    Min Zhou & Xiangquan Kong

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  1. Yue Hu
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  2. Min Zhou
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Correspondence to Li Liu.

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Yue Hu and Min Zhou contributed equally to this work and should be considered co-first authors.

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Hu, Y., Zhou, M., Li, K. et al. Two DNA repair gene polymorphisms on the risk of gastrointestinal cancers: a meta-analysis. Tumor Biol. 35, 1715–1725 (2014). https://doi.org/10.1007/s13277-013-1320-z

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