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Tumor Biology

, Volume 35, Issue 3, pp 2379–2382 | Cite as

Cerebral radiation injury and changes in the brain tissues of rat models with glioma

  • Lin Sha
  • Qian Cao
  • Li Lv
  • Guoguang Fan
Research Article

Abstract

Cerebral radiation injury (CRI) is a crucial and common complication of radiotherapy for patients with glioma. In the study, we aimed to investigate the changes in the diffusion-weighted imaging (DWI) and perfusion-weighted imaging (PWI) and the histological changes in the brain tissues of mice models with glioma. After the tumor cell seeding, there was an obvious increase in the proportion of cellular nucleus in the brain tissues of rat models with glioma. There was also an obvious increase in the microvascular density (MVD) in the brain tissues of rat models with glioma. There was a linear correlation between the mean apparent diffusion coefficient value and the proportion of cellular nucleus in the brain tissues of rat models with glioma (P < 0.05). There was also a linear correlation between the maximal relative cerebral volume and MVD count in the brain tissues of rat models with glioma (P < 0.01). Therefore, the changes in the DWI and PWI are related with the histological changes in the brain tissues of glioma, and the finding may help us make a distinction between postoperative recurrent glioma and CRI.

Keywords

Glioma Cerebral radiation injury Microvascular density Radiotheraphy 

Notes

Conflicts of interest

None

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2013

Authors and Affiliations

  1. 1.Department of Radiologythe Second Affiliated Hospital of Dalian Medical UniversityDalianPeople’s Republic of China
  2. 2.China Medical UniversityShenyangPeople’s Republic of China
  3. 3.Department of Pathologythe Second Affiliated Hospital of Dalian Medical UniversityDalianPeople’s Republic of China
  4. 4.Department of Radiologythe First Affiliated Hospital of China Medical UniversityShenyangPeople’s Republic of China

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