Tumor Biology

, Volume 35, Issue 3, pp 2359–2366 | Cite as

Association between glutathione S-transferase T1 null genotype and risk of lung cancer: a meta-analysis of 55 studies

  • Hongmei Yang
  • Xiaoyu Shen
  • Binru Li
  • Rui Ma
Research Article


The relationship between glutathione S-transferase T1 (GSTT1) gene polymorphism and the risk of lung cancer from the published reports are still conflicting. This study was conducted to evaluate the relationship between GSTT1 polymorphism and the risk of lung cancer. A comprehensive research was conducted through the databases, and 55 studies were recruited into this meta-analysis for the association of null genotype of GSTT1 with lung cancer susceptibility, consisting of 15,140 patients with lung cancer and 16,662 controls. There was a significant association between GSTT1 null genotype and lung cancer risk in the overall populations (OR = 1.138, 95 % CI = 1.032–1.255, P heterogeneity = 0.000, P = 0.009). Furthermore, GSTT1 null genotype was associated with the lung cancer risk in Asians (OR = 1.469, 95 % CI = 1.228–1.757, P heterogeneity = 0.000, P = 0.000). However, GSTT1 null genotype was not associated with the risk of lung cancer in Caucasians and Africans. In conclusion, GSTT1 null genotype is associated with the lung cancer in overall populations and in Asians.


Lung cancer Glutathione S-transferase T1 Susceptibility Polymorphism Meta-analysis 


Conflicts of interest



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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2013

Authors and Affiliations

  1. 1.Department of Internal MedicineLiaoning Provincial Tumor HospitalLiaoningChina

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