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Prognostic role of D-dimer in patients with lung cancer: a meta-analysis

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Tumor Biology

Abstract

D-dimer detection in patients suffering from a variety of different types of cancer has become a hot point as an emerging and promising biomarker. In this study, therefore, we evaluated the prognostic role of D-dimer in lung cancer. Initial literature was identified using the PubMed, EMBASE, and CNKI. The primary data was hazard ratio (HR) with 95 % confidence interval (CI) of survival outcomes in candidate articles, including overall survival (OS) and disease-free survival (DFS). Finally, 11 eligible studies were included in this meta-analysis, which were published between 1996 and 2013. The estimated pooled HR and 95 % CI for OS of all studies was 2.06 (95 % CI 1.64–2.58, p < 0.00001) and the HR and 95 % CI for DFS in one study was 3.38 (95 % CI 1.17–9.75, p = 0.002). The HRs and 95 % CIs for OS in Asian and non-Asian patients were 2.48 (95 % CI 1.60–3.84, p < 0.0001) and 1.89 (95 % CI 1.44–2.47, p < 0.00001), respectively. When we further analyzed the data by various detecting methods, the pooled HR and 95 % CI for OS were 3.22 (95 % CI 1.99–5.21, p < 0.00001) for ELISA, 1.52 (95 % CI 1.25–1.86, p < 0.0001) for Latex assay, and 1.79 (95 % CI 1.19–2.69, p = 0.005) for immunoturbidimetry assay. We also did subgroup analysis according to the ratio of histological type and clinical stage. All the above analysis had positive results. This meta-analysis showed that D-dimer had a fine predictive role in lung cancer patients, especially in Asian group. Also, it demonstrated that D-dimer had a stronger predictive value by using the method ELISA.

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Authors and Affiliations

  1. Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, No. 37 Guoxue Alley, Chengdu, 610041, People’s Republic of China

    Xuelei Ma, Yanyan Li, Jing Zhang, Jingwen Huang & Lei Liu

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  1. Xuelei Ma
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  2. Yanyan Li
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  3. Jing Zhang
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  5. Lei Liu
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Correspondence to Lei Liu.

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Xuelei Ma, Yanyan Li, and Jing Zhang contributed equally to this work.

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Ma, X., Li, Y., Zhang, J. et al. Prognostic role of D-dimer in patients with lung cancer: a meta-analysis. Tumor Biol. 35, 2103–2109 (2014). https://doi.org/10.1007/s13277-013-1279-9

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  • DOI: https://doi.org/10.1007/s13277-013-1279-9

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