Tumor Biology

, Volume 35, Issue 3, pp 2081–2086 | Cite as

Association between glutathione S-transferase T1 null genotype and glioma susceptibility: a meta-analysis

  • Benping Zhang
  • Jianjiao Wang
  • Hongshuang Niu
  • Yang Li
  • Fei Yuan
  • Yu Tian
  • Fenggang Zhou
  • Zhen Hao
  • Yongri Zheng
  • Qingsong Li
  • Weizhi Wang
Research Article

Abstract

The relationship between genetic polymorphisms of glutathione S-transferase (GST) and the development of glioma has been investigated in several epidemiologic studies. However, these studies report inconsistent results. In order to get this precise result, a meta-analysis was conducted by calculating the pooled odds ratios (OR) and the 95 % confidence intervals (95 % CI). Eleven case–control research studies with a total of 2,416 glioma cases and 4,850 controls were included into this meta-analysis. The combined results based on all studies showed that there was no significant association between the GSTT1 null allele and glioma risk (OR = 1.188, 95 % CI = 0.929–1.520, P heterogeneity = 0.003, P = 0.170). In the subgroup analysis, the same results were found in our work. There was no risk of publication bias in this meta-analysis. Our results suggest that GSTT1 null genotype was not associated with the increased risk of glioma.

Keywords

Glioma Susceptibility Glutathione S-transferase T1 Polymorphism Meta-analysis 

Notes

Conflicts of interest

None

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2013

Authors and Affiliations

  • Benping Zhang
    • 1
  • Jianjiao Wang
    • 1
  • Hongshuang Niu
    • 2
  • Yang Li
    • 1
  • Fei Yuan
    • 1
  • Yu Tian
    • 1
  • Fenggang Zhou
    • 1
  • Zhen Hao
    • 1
  • Yongri Zheng
    • 1
  • Qingsong Li
    • 1
  • Weizhi Wang
    • 1
  1. 1.Department of Neurology, The 2nd Affiliated HospitalHarbin Medical UniversityHarbinChina
  2. 2.Department of Emergency, The 2nd Affiliated HospitalHarbin Medical UniversityHarbinChina

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