Abstract
Vascular endothelial growth factor (VEGF) plays a crucial role in the regulation of angiogenesis and is involved in the development and metastasis of common cancers. There were several case–controls studies published to assess the associations of VEGF polymorphisms with risk of prostate cancer, but the findings were inconsistent. We performed a meta-analysis to provide a comprehensive assessment of the associations of three VEGF polymorphisms with risk of prostate cancer. The pooled odds ratio (OR) with 95 % confidence interval (95 % CI) was calculated to assess the associations. Eleven individual case–control studies with a total of 5,209 cases of prostate cancer and 5,233 controls were finally included into our meta-analysis. Overall, VEGF rs833061 polymorphism was not associated with risk of prostate cancer (T versus C, OR = 1.14, 95 % CI 0.91–1.44, P = 0.26; TT versus CC, OR = 1.09, 95 % CI 0.67–1.76, P = 0.74; TT versus CC/CT: OR = 1.46, 95 % CI 0.67–3.18, P = 0.34; TT/CT versus CC, OR = 1.08, 95 % CI 0.82–1.43, P = 0.59). VEGF rs3025039 polymorphism was also not associated with risk of prostate cancer (T versus C, OR = 1.03, 95 % CI 0.91–1.16, P = 0.66; TT versus CC, OR = 1.82 95 % CI 0.16–20.53, P = 0.63; TT versus CC/CT, OR = 2.00, 95 % CI 0.18–22.41, P = 0.57; TT/CT versus CC, OR = 0.72, 95 % CI 0.38–1.36, P = 0.31). VEGF rs2010963 polymorphism was not associated with risk of prostate cancer under three models (C versus G, OR = 1.17, 95 % CI 0.92–1.48, P = 0.20; CC versus GG, OR = 2.28, 95 % CI 0.90–5.75, P = 0.08; CC versus GG/GC, OR = 1.57, 95 % CI 0.67–3.68, P = 0.30). In conclusison, current data suggest that those three VEGF polymorphisms are not obviously associated with risk of prostate cancer.
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Chen, GQ., Luo, Jb., Wang, GZ. et al. Assessment of the associations between three VEGF polymorphisms and risk of prostate cancer. Tumor Biol. 35, 1875–1879 (2014). https://doi.org/10.1007/s13277-013-1250-9
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DOI: https://doi.org/10.1007/s13277-013-1250-9