Tumor Biology

, Volume 35, Issue 2, pp 1517–1521 | Cite as

Association between IL-4 -590C>T polymorphism and gastric cancer risk

  • Zihan Sun
  • Yuling Cui
  • Xiaohong Jin
  • Jing Pei
Research Article


Published studies on the association between interleukin-4 (IL-4) -590C>T polymorphism and gastric cancer risk have yielded conflicting results. Thus, a meta-analysis of published studies was performed to assess the possible association. All eligible studies of -590C>T polymorphism and gastric cancer risk were collected from the PubMed, the Cochrane Library, and the Embase electronic databases. Statistical analyses were performed by Review Manager 5.0 and Stata 11.0. When all groups were pooled, we did not detect a significant association of -590C>T polymorphism with gastric cancer risk. When stratifying for race, there was a significant association between -590C>T polymorphism and decreased gastric cancer risk under dominant model and allelic model in the subgroup of Caucasians. However, significant association was absent in Asians. Based on our meta-analysis, -590C>T polymorphism was associated with a lower gastric cancer risk under dominant model and allelic model in Caucasians. Nevertheless, we suggest that further studies should be made to confirm these findings.


IL-4 Polymorphism Gastric cancer Meta-analysis Association 


Conflicts of interest



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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2013

Authors and Affiliations

  • Zihan Sun
    • 1
  • Yuling Cui
    • 2
  • Xiaohong Jin
    • 3
  • Jing Pei
    • 2
    • 3
  1. 1.Department of laboratory diagnosisGeneral Hospital of Jinan Military RegionShandongChina
  2. 2.Department of Prevention and Health Care District 3, Centers for Disease Control and PreventionJinan Military RegionShandongChina
  3. 3.Department of Health District 3General Hospital of Jinan Military RegionShandongChina

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