Tumor Biology

, Volume 35, Issue 2, pp 1427–1432 | Cite as

Quantitative assessment of the association between XPC Lys939Gln polymorphism and cutaneous melanoma risk

  • Ling Zhou
  • Yuangang Lu
  • Guihong Yang
  • Jinjin Wu
Research Article


Previous studies evaluating the association between XPC Lys939Gln polymorphism and cutaneous melanoma risk reported conflicting findings. We searched PubMed and Embase databases up to May 16, 2013 to identify eligible studies on the association between XPC Lys939Gln polymorphism and cutaneous melanoma risk. Finally, a total of seven case–control studies including 3,971 cases of cutaneous melanoma and 5,873 controls were included in the meta-analysis. Statistical analysis was performed with STATA version 11.0. Odds ratios (ORs) with 95 % confidence intervals (95 % CIs) were used to assess the strength of the association. Overall, there was no association between XPC Lys939Gln polymorphism and cutaneous melanoma risk under all five genetic models (Gln vs. Lys: OR = 1.11, 95 % CI = 0.98–1.26, P = 0.10; GlnGln vs. LysLys: OR = 1.26, 95 % CI = 0.98–1.61, P = 0.07; LysGln vs. LysLys: OR = 1.04, 95 % CI = 0.88–1.22, P = 0.64; GlnGln/LysGln vs. LysLys: OR = 1.10, 95 % CI = 0.92–1.31, P = 0.29; GlnGln vs. LysLys/LysGln: OR = 1.19, 95 % CI = 0.99–1.43, P = 0.06). Subgroup analysis in Caucasians showed that there was an obvious association between XPC Lys939Gln polymorphism and cutaneous melanoma risk in Caucasians (GlnGln vs. LysLys/LysGln: OR = 1.12, 95 % CI = 1.00–1.25, P = 0.05). Sensitivity analysis by omitting one study in turns showed that the significance of the pooled ORs was not stable. In addition, there was some evidence of publication bias in the meta-analysis, and meta-analyses of the studies with large sample size did not find the obvious association between XPC Lys939Gln polymorphism and cutaneous melanoma risk in Caucasians. Therefore, there is little evidence for the association between XPC Lys939Gln polymorphism and cutaneous melanoma risk.


XPC Lys939Gln Polymorphism Cutaneous melanoma Meta-analysis 


Conflicts of interest

The authors have declared that no competing interests exist.


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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2013

Authors and Affiliations

  • Ling Zhou
    • 1
  • Yuangang Lu
    • 1
  • Guihong Yang
    • 1
  • Jinjin Wu
    • 1
  1. 1.Department of Dermatology, Daping HospitalThird Military Medical UniversityDapingPeople’s Republic of China

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