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XRCC1 polymorphisms and cervical cancer risk: an updated meta-analysis

Tumor Biology volume 35, pages 1221–1231 (2014)Cite this article

Abstract

X-ray repair cross complementing 1 (XRCC1) plays a key role in DNA repair, genetic instability and tumorigenesis. A series of epidemiological studies have examined associations between XRCC1 polymorphisms and cervical cancer risk, but the findings remain inconclusive. We searched three electronic databases (MEDLINE, EMBASE and CNKI) for studies on the association between XRCC1 polymorphisms and cervical cancer risk published before June 2013. Pooled odds ratio (OR) and 95 % confidence interval (CI) were calculated to estimate risk associations. A total of 28 case–control studies from 15 publications with 5,890 cervical cancer cases and 7,626 controls were identified. There was a significant association between rs25487 and cervical cancer risk in Asian populations (Dominant model: OR = 1.25, 95 % CI =1.04–1.50, P = 0.051 for heterogeneity test). After excluding three studies deviated from Hardy–Weinberg equilibrium, we observed a significant association of rs1799782 with cervical cancer risk in all populations and in Asian populations (Recessive model: OR = 1.62 and 1.72, 95 % CI = 1.22–2.14 and 1.29–2.30, P = 0.090 and 0.266 for heterogeneity test, respectively). However, there was no significant association between rs25489 and cervical cancer risk. These findings were further confirmed by false-positive report probability analysis. No publication bias was found by using the funnel plot and Egger's test. This meta-analysis provides strongly statistical evidence for the association between rs1799782 and cervical cancer risk, as well as its association with rs25487 only in Asian populations. However, single large, well-designed prospective studies are needed to confirm these findings.

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Abbreviations

HPV:

Human papillomavirus

SNP:

Single nucleotide polymorphism

BER:

Base excision repair

XRCC1:

X-ray repair cross complementing 1

OR:

Odds ratio

CI:

Confidence interval

PB:

Population-based

HB:

Hospital-based

HWE:

Hardy–Weinberg equilibrium

FPRP:

False-positive report probability

PCR:

Polymerase chain reaction

RFLP:

Restriction fragment length polymorphism

MAF:

Minor allele frequency

PARP:

Poly(ADP-ribose) polymerases

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Acknowledgments

This study was supported by the grant from "Foreign Cooperation Projects" Recruitment at Wenzhou Municipal Science and Technology Bureau (H20070036).

Conflicts of interest

None

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Affiliations

  1. Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, 109 West Xueyuan Road, Wenzhou, 325300, Zhejiang, China

    Jie Mei, Ling-Ling Wang, Sen Yang, Jie-Qiang Lu & Yu Zhao

  2. Department of Obstetrics and Gynecology, Number 4 Hospital, Xi’an, China

    Hai-Xia Duan

  3. Department of Gynecologic Oncology, Fudan University Shanghai Cancer Center, 270 Dong An Road, Shanghai, 200032, China

    Ting-Yan Shi

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  1. Jie Mei
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  2. Hai-Xia Duan
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  4. Sen Yang
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  5. Jie-Qiang Lu
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Correspondence to Ting-Yan Shi or Yu Zhao.

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Mei, J., Duan, HX., Wang, LL. et al. XRCC1 polymorphisms and cervical cancer risk: an updated meta-analysis. Tumor Biol. 35, 1221–1231 (2014). https://doi.org/10.1007/s13277-013-1163-7

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  • DOI: https://doi.org/10.1007/s13277-013-1163-7

Keywords

  • XRCC1
  • DNA repair
  • Polymorphism
  • Cervical cancer
  • Meta-analysis