Tumor Biology

, Volume 35, Issue 2, pp 1149–1155 | Cite as

Association between Cyclin D1 polymorphism and oral cancer susceptibility: a meta-analysis

  • Lili Wang
  • Zhiying Wang
  • Xiuqiu Gao
  • Xin Li
  • Xirao Sun
  • Changfu Liu
Research Article


Data from several case–control studies on the relation between the Cyclin D1 (CCND1) G870A polymorphism and oral cancer susceptibility implicated conflicting conclusions. Thus, a meta-analysis was performed to derive a more precise evaluation of the association. We searched PubMed and Embase for related studies that had been published in English and eight available studies were finally included in the meta-analysis. Odd ratios (ORs) and 95 % confidence intervals (CIs) were calculated for each study. Our meta-analysis suggested that CCND1 G870A polymorphism was not associated with oral cancer risk (OR AA vs. GG = 1.08, 95 % CI = 0.90–1.30, P heterogeneity = 0.175; OR AA + GA vs. GG = 1.02, 95 % CI = 0.91–1.14, P heterogeneity = 0.781; OR AA vs. GA + GG = 1.16, 95 % CI = 0.98–1.36, P heterogeneity = 0.107; OR A vs. G = 1.05 95 % CI = 0.96–1.15, P heterogeneity = 0.211; OR GA vs. GG = 0.94, 95 % CI = 0.82–1.08, P heterogeneity = 0.935). However, in the subgroup analysis by ethnicity, possible significance among Asian groups was indicated in two genetic models (OR AA vs. GA + GG = 1.27, 95 % CI = 1.05–1.54, P heterogeneity = 0.572; OR allele A vs. allele G = 1.11, 95 % CI = 1.00–1.24, P heterogeneity = 0.211). Taken together, the meta-analysis revealed that CCND1 G870A polymorphism might be correlated with the susceptibility of oral cancer in Asians.


CCND1 G870A Polymorphism Susceptibility Oral cancer 



This work was supported by Liaoning Medical University Youth Science and Technology Foundation (no. Y2012Z008), Liaoning Foundation of Education Department (no. L2012309), Liaoning Natural Science Fund Project (no. 20102135), and Liaoning Natural Science Fund Project of Science and Technology (no. 2013022029).

Conflicts of interest



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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2013

Authors and Affiliations

  • Lili Wang
    • 1
  • Zhiying Wang
    • 2
  • Xiuqiu Gao
    • 3
  • Xin Li
    • 1
  • Xirao Sun
    • 3
  • Changfu Liu
    • 4
  1. 1.Department of Prosthodontics, the Affiliated Hospital of Stomatology and The Second Affiliated HospitalLiaoning Medical UniversityJinzhouChina
  2. 2.Department of Oral Implantology, the Affiliated Hospital of Stomatology and The Second Affiliated HospitalLiaoning Medical UniversityJinzhouChina
  3. 3.Department of Comprehensive Dentistry and Oral Medicine, the Affiliated Hospital of Stomatology and The Second Affiliated HospitalLiaoning Medical UniversityJinzhouChina
  4. 4.Department of Oral and Maxillofacial Surgery, the Affiliated Hospital of StomatologyLiaoning Medical UniversityJinzhouChina

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