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Tumor Biology

, Volume 35, Issue 2, pp 1149–1155 | Cite as

Association between Cyclin D1 polymorphism and oral cancer susceptibility: a meta-analysis

  • Lili Wang
  • Zhiying Wang
  • Xiuqiu Gao
  • Xin Li
  • Xirao Sun
  • Changfu Liu
Research Article

Abstract

Data from several case–control studies on the relation between the Cyclin D1 (CCND1) G870A polymorphism and oral cancer susceptibility implicated conflicting conclusions. Thus, a meta-analysis was performed to derive a more precise evaluation of the association. We searched PubMed and Embase for related studies that had been published in English and eight available studies were finally included in the meta-analysis. Odd ratios (ORs) and 95 % confidence intervals (CIs) were calculated for each study. Our meta-analysis suggested that CCND1 G870A polymorphism was not associated with oral cancer risk (OR AA vs. GG = 1.08, 95 % CI = 0.90–1.30, P heterogeneity = 0.175; OR AA + GA vs. GG = 1.02, 95 % CI = 0.91–1.14, P heterogeneity = 0.781; OR AA vs. GA + GG = 1.16, 95 % CI = 0.98–1.36, P heterogeneity = 0.107; OR A vs. G = 1.05 95 % CI = 0.96–1.15, P heterogeneity = 0.211; OR GA vs. GG = 0.94, 95 % CI = 0.82–1.08, P heterogeneity = 0.935). However, in the subgroup analysis by ethnicity, possible significance among Asian groups was indicated in two genetic models (OR AA vs. GA + GG = 1.27, 95 % CI = 1.05–1.54, P heterogeneity = 0.572; OR allele A vs. allele G = 1.11, 95 % CI = 1.00–1.24, P heterogeneity = 0.211). Taken together, the meta-analysis revealed that CCND1 G870A polymorphism might be correlated with the susceptibility of oral cancer in Asians.

Keywords

CCND1 G870A Polymorphism Susceptibility Oral cancer 

Notes

Funding

This work was supported by Liaoning Medical University Youth Science and Technology Foundation (no. Y2012Z008), Liaoning Foundation of Education Department (no. L2012309), Liaoning Natural Science Fund Project (no. 20102135), and Liaoning Natural Science Fund Project of Science and Technology (no. 2013022029).

Conflicts of interest

None

References

  1. 1.
    Akkiz H, Bayram S, Bekar A, Akgollu E, Ozdil B. Cyclin D1 G870A polymorphism is associated with an increased risk of hepatocellular carcinoma in the Turkish population: case–control study. Cancer Epidemiol. 2010;34(3):298–302.PubMedCrossRefGoogle Scholar
  2. 2.
    Balcerczak E, Pasz-Walczak G, Kumor P, Panczyk M, Kordek R, Wierzbicki R, et al. Cyclin D1 protein and CCND1 gene expression in colorectal cancer. Eur J Surg Oncol J Eur Soc Surg Oncol B Assoc Surg Oncol. 2005;31(7):721–6.Google Scholar
  3. 3.
    Bizari L, Borim AA, Leite KR, Goncalves Fde T, Cury PM, Tajara EH, et al. Alterations of the CCND1 and HER-2/neu (ERBB2) proteins in esophageal and gastric cancers. Cancer Genet Cytogenet. 2006;165(1):41–50.PubMedCrossRefGoogle Scholar
  4. 4.
    Canbay E, Eraltan IY, Cercel A, Isbir T, Gazioglu E, Aydogan F, et al. CCND1 and CDKN1B polymorphisms and risk of breast cancer. Anticancer Res. 2010;30(7):3093–8.PubMedGoogle Scholar
  5. 5.
    Caplan DJ, Hertz-Picciotto I. Racial differences in survival of oral and pharyngeal cancer patients in North Carolina. J Public health Dent. 1998;58(1):36–43.PubMedCrossRefGoogle Scholar
  6. 6.
    Ceschi M, Sun CL, Van Den Berg D, Koh WP, Yu MC, Probst-Hensch N. The effect of cyclin D1 (CCND1) G870A-polymorphism on breast cancer risk is modified by oxidative stress among Chinese women in Singapore. Carcinogenesis. 2005;26(8):1457–64.PubMedCrossRefGoogle Scholar
  7. 7.
    Cui J, Shen L, Wang Y. Specific CCND1 G870A alleles associated with breast cancer susceptibility: a meta-analysis of 5,528 cases and 5,353 controls. Asian Pac J Cancer Prev APJCP. 2012;13(10):5023–5.CrossRefGoogle Scholar
  8. 8.
    Franceschi S, Talamini R, Barra S, Baron AE, Negri E, Bidoli E, et al. Smoking and drinking in relation to cancers of the oral cavity, pharynx, larynx, and esophagus in northern Italy. Cancer Res. 1990;50(20):6502–7.PubMedGoogle Scholar
  9. 9.
    Gomes CC, Drummond SN, Guimaraes AL, Andrade CI, Mesquita RA, Gomez RS. P21/WAF1 and cyclin D1 variants and oral squamous cell carcinoma. J Oral Pathol Med Off Publ Int Assoc Oral Pathol Am Acad Oral Pathol. 2008;37(3):151–6.CrossRefGoogle Scholar
  10. 10.
    Holley SL, Matthias C, Jahnke V, Fryer AA, Strange RC, Hoban PR. Association of cyclin D1 polymorphism with increased susceptibility to oral squamous cell carcinoma. Oral Oncol. 2005;41(2):156–60.PubMedCrossRefGoogle Scholar
  11. 11.
    Liao CT, Wang HM, Ng SH, Yen TC, Lee LY, Hsueh C, et al. Good tumor control and survivals of squamous cell carcinoma of buccal mucosa treated with radical surgery with or without neck dissection in Taiwan. Oral Oncol. 2006;42(8):800–9.PubMedCrossRefGoogle Scholar
  12. 12.
    Liu W, Zhu E, Wang R, Wang L, Gao L, Yang X, et al. Cyclin D1 gene polymorphism, A870G, is associated with an increased risk of salivary gland tumors in the Chinese population. Cancer Epidemiol. 2011;35(4):e12–7.PubMedCrossRefGoogle Scholar
  13. 13.
    Lu F, Gladden AB, Diehl JA. An alternatively spliced cyclin D1 isoform, cyclin D1b, is a nuclear oncogene. Cancer Res. 2003;63(21):7056–61.PubMedGoogle Scholar
  14. 14.
    Matthias C, Branigan K, Jahnke V, Leder K, Haas J, Heighway J, et al. Polymorphism within the cyclin D1 gene is associated with prognosis in patients with squamous cell carcinoma of the head and neck. Clin Cancer Res Off J Am Assoc Cancer Res. 1998;4(10):2411–8.Google Scholar
  15. 15.
    Moore RJ, Doherty DA, Do KA, Chamberlain RM, Khuri FR. Racial disparity in survival of patients with squamous cell carcinoma of the oral cavity and pharynx. Ethn health. 2001;6(3–4):165–77.PubMedCrossRefGoogle Scholar
  16. 16.
    Nishimoto IN, Pinheiro NA, Rogatto SR, Carvalho AL, Simpson AJ, Caballero OL, et al. Cyclin D1 gene polymorphism as a risk factor for squamous cell carcinoma of the upper aerodigestive system in non-alcoholics. Oral Oncol. 2004;40(6):604–10.PubMedCrossRefGoogle Scholar
  17. 17.
    Noel EE, Yeste-Velasco M, Mao X, Perry J, Kudahetti SC, Li NF, et al. The association of CCND1 overexpression and cisplatin resistance in testicular germ cell tumors and other cancers. Am J Pathol. 2010;176(6):2607–15.PubMedCrossRefGoogle Scholar
  18. 18.
    Sathyan KM, Nalinakumari KR, Abraham T, Kannan S. Influence of single nucleotide polymorphisms in H-Ras and cyclin D1 genes on oral cancer susceptibility. Oral Oncol. 2006;42(6):607–13.PubMedCrossRefGoogle Scholar
  19. 19.
    Sherr CJ. D-type cyclins. Trends Biochem Sci. 1995;20(5):187–90.PubMedCrossRefGoogle Scholar
  20. 20.
    Sherr CJ. Cancer cell cycles. Science. 1996;274(5293):1672–7.PubMedCrossRefGoogle Scholar
  21. 21.
    Shiboski CH, Shiboski SC, Silverman Jr S. Trends in oral cancer rates in the United States, 1973–1996. Community Dent Oral Epidemiol. 2000;28(4):249–56.PubMedCrossRefGoogle Scholar
  22. 22.
    Solomon DA, Wang Y, Fox SR, Lambeck TC, Giesting S, Lan Z, et al. Cyclin D1 splice variants. Differential effects on localization, RB phosphorylation, and cellular transformation. J Biol Chem. 2003;278(32):30339–47.PubMedCrossRefGoogle Scholar
  23. 23.
    Sutherland RL, Musgrove EA. Cyclin D1 and mammary carcinoma: new insights from transgenic mouse models. Breast Cancer Res BCR. 2002;4(1):14–7.CrossRefGoogle Scholar
  24. 24.
    Swango PA. Cancers of the oral cavity and pharynx in the United States: an epidemiologic overview. J Public health Dent. 1996;56(6):309–18.PubMedCrossRefGoogle Scholar
  25. 25.
    Tsai MH, Tsai CW, Tsou YA, Hua CH, Hsu CF, Bau DT. Significant association of cyclin D1 single nucleotide polymorphisms with oral cancer in Taiwan. Anticancer Res. 2011;31(1):227–31.PubMedGoogle Scholar
  26. 26.
    Wang L, Habuchi T, Mitsumori K, Li Z, Kamoto T, Kinoshita H, et al. Increased risk of prostate cancer associated with AA genotype of cyclin D1 gene A870G polymorphism. Int J Cancer J Int Cancer. 2003;103(1):116–20.CrossRefGoogle Scholar
  27. 27.
    Wang L, Habuchi T, Takahashi T, Mitsumori K, Kamoto T, Kakehi Y, et al. Cyclin D1 gene polymorphism is associated with an increased risk of urinary bladder cancer. Carcinogenesis. 2002;23(2):257–64.PubMedCrossRefGoogle Scholar
  28. 28.
    Wang W, Zhao Y, Yang J, Lin B, Gu H, Cao X, et al. Cyclin D1 polymorphism and oral cancer: a meta-analysis. Mol Biol Rep. 2013;40(1):87–95.PubMedCrossRefGoogle Scholar
  29. 29.
    Wong YK, Lin SC, Chang CS, Tseng YH, Liu CJ, Lin HC, et al. Cyclin D1 genotype in areca-associated oral squamous cell carcinoma. J Oral Pathol Med Off Publ Int Assoc Oral Pathol Am Acad Oral Pathol. 2003;32(5):265–70.CrossRefGoogle Scholar
  30. 30.
    Zhuo XL, Ling JJ, Zhao HY, Zhou Y, Song YF, Tan YH. Lack of association of the cyclin D1 G870A variation with oral carcinoma risk: Evidence from 2,404 subjects. Exp Ther Med. 2012;4(4):748–54.PubMedCentralPubMedGoogle Scholar

Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2013

Authors and Affiliations

  • Lili Wang
    • 1
  • Zhiying Wang
    • 2
  • Xiuqiu Gao
    • 3
  • Xin Li
    • 1
  • Xirao Sun
    • 3
  • Changfu Liu
    • 4
  1. 1.Department of Prosthodontics, the Affiliated Hospital of Stomatology and The Second Affiliated HospitalLiaoning Medical UniversityJinzhouChina
  2. 2.Department of Oral Implantology, the Affiliated Hospital of Stomatology and The Second Affiliated HospitalLiaoning Medical UniversityJinzhouChina
  3. 3.Department of Comprehensive Dentistry and Oral Medicine, the Affiliated Hospital of Stomatology and The Second Affiliated HospitalLiaoning Medical UniversityJinzhouChina
  4. 4.Department of Oral and Maxillofacial Surgery, the Affiliated Hospital of StomatologyLiaoning Medical UniversityJinzhouChina

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