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Tumor Biology

, Volume 35, Issue 1, pp 849–858 | Cite as

Quantitative assessment of the influence of glutathione S-transferase T1 null variant on gastric cancer risk

  • Qing Wang
  • Ying Chen
  • Yong Zhang
  • Weiqiang Xu
  • Hua He
  • Xu Li
  • Hengguan Cui
Research Article

Abstract

Glutathione S-transferase T1 (GSTT1) catalyzes reactions between glutathione and lipophilic compounds with electrophilic centers, leading to neutralization of toxic compounds, xenobiotics, and products of oxidative stress. In the past decade, a number of case–control studies have been carried out to investigate the relationship between the GSTT1 null polymorphism and gastric cancer (GC), but the results have been inconclusive. To investigate this inconsistency, we performed a meta-analysis of 46 studies involving a total of 9012 GC cases and 14,215 controls for null variant of the GSTT1 gene to evaluate the effect of GSTT1 on genetic susceptibility for GC. Potential sources of heterogeneity including ethnicity, source of control, and sample size were also assessed. Overall, significantly increased GC risk was associated with GSTT1 null polymorphism with OR of 1.20 (95 % CI, 1.10–1.32; P < 0.05). In the subgroup analysis by ethnicity, significantly increased risks were found in East Asians and Indians, while no significant associations were found among Caucasian, and Middle Eastern and African populations. By pooling data from 19 studies that considered combinations of GSTT1 and GSTM1 genotypes, a statistically significant increased risk for GC (OR = 2.04, 95 % CI, 1.49–2.64; P < 0.05) was detected for individuals with dual deletion in both genes compared with positive genotypes. In addition, we found that cigarette smoking and alcohol drinking may modified the association of GSTT1 null genotypes with the risk of GC. In conclusion, this meta-analysis suggests that GSTT1 null polymorphism is associated with elevated GC risk, but these associations vary in different ethnic populations.

Keywords

Gastric cancer GSTT1 Polymorphism Meta-analysis 

Notes

Acknowledgments

This work was supported by the National Natural Science Foundation of China (81201535) and Shanghai Natural Science Foundation (12ZR1436000).

Conflicts of interest

None

Supplementary material

13277_2013_1118_MOESM1_ESM.doc (368 kb)
ESM 1 (DOC 368 kb)

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2013

Authors and Affiliations

  • Qing Wang
    • 1
  • Ying Chen
    • 1
  • Yong Zhang
    • 2
  • Weiqiang Xu
    • 1
  • Hua He
    • 1
  • Xu Li
    • 1
  • Hengguan Cui
    • 1
  1. 1.Department of Surgery, Qingpu Branch of Zhongshan HospitalFudan UniversityShanghaiPeople’s Republic of China
  2. 2.Department of General Surgery, Branch of Zhongshan HospitalFudan UniversityShanghaiPeople’s Republic of China

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