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Tumor Biology

, Volume 35, Issue 1, pp 831–835 | Cite as

A let-7 KRAS rs712 polymorphism increases colorectal cancer risk

  • Xin-Min Pan
  • Rui-Fen Sun
  • Zhao-Hui Li
  • Xiao-Min Guo
  • Zhen Zhang
  • Hao-Jie Qin
  • Guo-Hui Xu
  • Lin-Bo Gao
Research Article

Abstract

Growing evidence has indicated that polymorphism present in the miRNA binding site of target gene can alter the ability of miRNAs to bind its target gene and modulate the development and progression of cancer. We aimed to investigate the association between let-7 KRAS rs712 polymorphism and the risk of colorectal cancer (CRC). The let-7 KRAS rs712 was analyzed in a case–control study, including 339 CRC patients and 313 age- and sex-matched controls; the relationship between the polymorphism and the clinicopathological features of CRC was also examined. Individuals carrying the let-7 KRAS rs712 TT genotype and T allele had an increased risk of developing CRC (TT vs. GG, adjusted OR = 2.18; 95 % CI, 1.00–4.77; T vs. G, adjusted OR = 1.50; 95 % CI, 1.15–1.96). Stratified analyses revealed that CRC patients with the let-7 KRAS rs712 TT genotype were more likely to have clinical stage III or IV disease (OR = 3.29, 95 % CI, 1.32–8.20) and distant metastasis (OR = 4.70, 95 % CI, 1.81–12.25). These findings provide evidence that the let-7 KRAS rs712 polymorphism may play crucial roles in the etiology of CRC.

Keywords

Single nucleotide polymorphism Let-7 KRAS Colorectal cancer 

Notes

Acknowledgments

This work was supported by National Natural Science Foundation of China (no. 81302149), Natural Science Foundation of the Science and Technology Department of Henan Province (no. 132300410105), the Ph.D. Scientific Research Foundation of Henan University of Science and Technology (no. 09001492).

Conflicts of interest

None

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2013

Authors and Affiliations

  • Xin-Min Pan
    • 1
  • Rui-Fen Sun
    • 2
  • Zhao-Hui Li
    • 3
  • Xiao-Min Guo
    • 4
  • Zhen Zhang
    • 1
  • Hao-Jie Qin
    • 1
  • Guo-Hui Xu
    • 1
  • Lin-Bo Gao
    • 5
  1. 1.Department of Forensic Pathology, College of Forensic MedicineHenan University of Science and TechnologyLuoyangPeople’s Republic of China
  2. 2.Central LaboratoryYunnan University of Chinese Traditional MedicineKunmingPeople’s Republic of China
  3. 3.Secondary Department of General SurgeryLuoyang Central Hospital Affiliated to Zhengzhou UniversityLuoyangPeople’s Republic of China
  4. 4.Department of OtolaryngologyThird Affiliated Hospital of Henan University of Science and Technology and Luo Yang East HospitalLuoyangPeople’s Republic of China
  5. 5.Laboratory of Molecular and Translational Medicine, West China Institute of Women and Children’s Health, Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of EducationWest China Second University Hospital of Sichuan UniversityChengduPeople’s Republic of China

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