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Tumor Biology

, Volume 35, Issue 1, pp 809–813 | Cite as

RETRACTED ARTICLE: Association between single-nucleotide polymorphisms of OGG1 gene and pancreatic cancer risk in Chinese Han population

  • Hongxu Chen
  • Bo Zhou
  • Xiang Lan
  • Dong Wei
  • Tao Yuan
  • Ping Chen
Research Article

Abstract

The purpose of this study was to test the association between single-nucleotide polymorphisms (SNPs) of 8-oxoguanine DNA glycosylase (OGG1) gene and susceptibility to pancreatic cancer (PC). A total of 347 PC patients and 364 healthy subjects were enrolled in this case–control study. The c.269C>A genetic variant was investigated using the created restriction site–polymerase chain reaction method. The c.627T>C genetic variant was identified by the polymerase chain reaction–restriction fragment length polymorphism method. Our data indicated that the alleles and genotypes frequencies of these two SNPs were statistically different in PC cases and controls. As for c.269C>A, the AA genotype was statistically associated with decreased PC susceptibility compared to CC wild genotype (odds ratio (OR) = 0.44, 95 % confidence interval (CI) 0.27–0.73, P = 0.001). As for c.627T>C, statistically significant decreased PC susceptibility was detected in CC genotype compared to TT wild genotype (OR = 0.57, 95 % CI 0.35–0.94, P = 0.028). The allele A of c.269C>A and allele C of c.627T>C might be associated with a protection from PC (for c.269C>A, A versus (vs.) C, OR = 0.69, 95 % CI 0.55–0.86, P < 0.001; for c.627T>C, C vs. T, OR = 0.72, 95 % CI 0.58–0.91, P = 0.005). Results from this study indicate that the c.269C>A and c.627T>C SNPs of OGG1 gene are associated with PC susceptibility in Chinese Han ethnicity.

Keywords

Pancreatic cancer OGG1 gene Single-nucleotide polymorphisms Cancer susceptibility 

Notes

Conflicts of interest

None

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2013

Authors and Affiliations

  • Hongxu Chen
    • 1
  • Bo Zhou
    • 1
  • Xiang Lan
    • 1
  • Dong Wei
    • 1
  • Tao Yuan
    • 1
  • Ping Chen
    • 1
  1. 1.Department of Hepatobiliary Surgery, Daping HospitalThe Third Military Medical UniversityChongqingPeople’s Republic of China

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