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Quantitative assessment of the influence of common variations on 6p21 and lung cancer risk

  • Research Article
  • Published:
Tumor Biology

Abstract

Genome-wide association studies have identified 6p21 as a new lung cancer susceptibility locus in populations of European descent. Since then, the relationship between common variations on 6p21 and lung cancer has been reported in various ethnic groups; however, these studies have yielded inconsistent results. To investigate this inconsistency, we performed a meta-analysis of 11 studies involving a total of 36,890 cases and 52,767 controls for three widely studies polymorphisms (rs4324798, rs3117582, and rs9295740) to evaluate its effect on genetic susceptibility for lung cancer. An overall random-effects per-allele odds ratio (OR) of 1.11 (95 % confidence interval (CI) 1.04–1.19; P = 0.002) and 1.20 (95 % CI 1.14–1.26; P < 10−5) was found for the rs4324798 and rs3117582 polymorphism, respectively. Marginal significant associations were also detected for rs9295740 with per-allele OR of 1.09 (95 % CI 1.01–1.18; P = 0.03). In the subgroup analysis by ethnicity, significantly increased risks were found for the three polymorphisms among Caucasians. Similar results were also observed using dominant or recessive genetic models. This meta-analysis demonstrated that the three common variations (rs4324798, rs3117582, and rs9295740) on 6p21 are risk factors associated with increased lung cancer susceptibility, but these associations vary in different ethnic populations.

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Authors and Affiliations

  1. Department of Thoracic Surgery, Shanghai Chest Hospital affiliated to Shanghai Jiao Tong University, Shanghai, 200030, People’s Republic of China

    Jicheng TanTai, Yuzhou Shen & Heng Zhao

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  1. Jicheng TanTai
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  2. Yuzhou Shen
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  3. Heng Zhao
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Correspondence to Heng Zhao.

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Jicheng TanTai and Yuzhou Shen contributed equally to this work.

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TanTai, J., Shen, Y. & Zhao, H. Quantitative assessment of the influence of common variations on 6p21 and lung cancer risk. Tumor Biol. 35, 689–694 (2014). https://doi.org/10.1007/s13277-013-1094-3

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  • DOI: https://doi.org/10.1007/s13277-013-1094-3

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