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Tumor Biology

, Volume 35, Issue 1, pp 595–601 | Cite as

Clinical characteristics and prognostic factors of prostate cancer with liver metastases

  • HaiTao Wang
  • BaoGuo Li
  • PengYu Zhang
  • YanHong Yao
  • JiWu Chang
Research Article

Abstract

Liver metastasis from prostate cancer is uncommon and remains poorly understood. We computer searched the clinical records of all our patients registered into a database to identify patients that presented or developed liver metastases. A total of 27 prostate cancer patients with ultrasound or CT/MR imaging evidence of liver metastases were included in our analysis. The liver metastasis rate from metastatic prostate cancer was 4.29 %. Eight (29.63 %) patients had previously untreated, hormone-naive prostate cancer (synchronous liver metastases at diagnosis of prostate cancer), whereas 19 (70.37 %) patients had already been diagnosed as having hormone-refractory prostate cancer. In the hormone-naive group, the median overall survival after liver metastases diagnosis was 38 months and half of the patients were still alive at the latest follow-up, whereas only 6 months in the hormone-refractory group (p = 0.003). High concentration of serum neuron-specific enolase and previous chemotherapy were associated with a significantly poor overall survival after liver metastases in the hormone-refractory group using Kaplan–Meier curves and logrank tests for univariate analysis.

Keywords

Liver metastases Prostate cancer Predictive factors Survival 

Notes

The study was supported by NSFC (81071787) and Tianjin Municipal Science and Technology Commission (08JCYBJC10300).

Conflicts of interest

None

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2013

Authors and Affiliations

  1. 1.Department of Interventional Oncology, Tianjin Cancer Hospital and InstituteTianjin Medical UniversityTianjinChina
  2. 2.Research Group of Evidence-based Clinical OncologyTianjinChina
  3. 3.Tianjin Key Laboratory of Cancer Prevention and TherapyTianjinChina
  4. 4.Tianjin Institute of Urological SurgeryTianjin Medical UniversityTianjinChina

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