Tumor Biology

, Volume 35, Issue 1, pp 345–349 | Cite as

RETRACTED ARTICLE: Meta-analysis of the association between GSTT1 null genotype and risk of nasopharyngeal carcinoma in Chinese

  • Bin Jin
  • Pin Dong
  • Keyong Li
  • Bin Shen
  • Jin Xie
Research Article


Glutathione S-transferase T1 (GSTT1) null genotype has been proven to be associated with risks of many cancers. There were also many studies assessing on the association between GSTT1 null genotype and nasopharyngeal carcinoma risk in Chinese, but the findings from those studies were inconsistent. We performed a meta-analysis to provide a more precise assessment on the effect of GSTT1 null genotype on nasopharyngeal carcinoma risk. The PubMed and Wanfang databases were searched to identify eligible case–control studies on the association between GSTT1 null genotype and risk of nasopharyngeal carcinoma in Chinese. The pooled odds ratios (OR) with corresponding 95 % confidence intervals (95 % CI) were used to assess the association. Eight case–control studies with a total of 3,702 individuals were finally included in the meta-analysis. Meta-analysis of a total of eight studies showed that GSTT1 null genotype was significantly associated with increased risk of nasopharyngeal carcinoma in Chinese (OR = 2.27; 95 % CI 1.41–3.67; P = 0.001). The finding from cumulative meta-analysis showed that there was a trend of more obvious association between GSTT1 null genotype and risk of nasopharyngeal carcinoma in Chinese as data accumulated by publication year. Therefore, the GSTT1 null genotype is significantly associated with increased risk of nasopharyngeal carcinoma in Chinese.


Nasopharyngeal carcinoma GSTT1 Meta-analysis 


Conflicts of interests



  1. 1.
    Chakroun A, Guigay J, Lusinchi A, Marandas P, Janot F, Hartl DM. Paraneoplastic dermatomyositis accompanying nasopharyngeal carcinoma: diagnosis, treatment and prognosis. Eur Ann Otorhinolaryngol Head Neck Dis. 2011;128:127–31.CrossRefPubMedGoogle Scholar
  2. 2.
    Jia WH, Qin HD. Non-viral environmental risk factors for nasopharyngeal carcinoma: a systematic review. Semin Cancer Biol. 2012;22:117–26.CrossRefPubMedGoogle Scholar
  3. 3.
    Yu WM, Hussain SS. Incidence of nasopharyngeal carcinoma in Chinese immigrants, compared with Chinese in China and South East Asia: review. J Laryngol Otol. 2009;123:1067–74.CrossRefPubMedGoogle Scholar
  4. 4.
    Cao SM, Simons MJ, Qian CN. The prevalence and prevention of nasopharyngeal carcinoma in China. Chin J Cancer. 2011;30:114–9.CrossRefPubMedPubMedCentralGoogle Scholar
  5. 5.
    Lee AW, Lin JC, Ng WT. Current management of nasopharyngeal cancer. Semin Radiat Oncol. 2012;22:233–44.CrossRefPubMedGoogle Scholar
  6. 6.
    Hayes JD, Flanagan JU, Jowsey IR. Glutathione transferases. Annu Rev Pharmacol Toxicol. 2005;45:51–88.CrossRefPubMedGoogle Scholar
  7. 7.
    Hayes JD, Strange RC. Glutathione s-transferase polymorphisms and their biological consequences. Pharmacology. 2000;61:154–66.CrossRefPubMedGoogle Scholar
  8. 8.
    8 Fang M, Zeng W, Huang L, Qin S, Zhou J, Sun H, Meng F: Association between glutathione S-transferase T1 null genotype and risk of myelodysplastic syndromes: a comprehensive meta-analysis. Tumour Biol 2013Google Scholar
  9. 9.
    Zhao Y, Luo Y, Huang B, Qin B, Zhang T, Zhang J, et al. GSTT1 null genotype contributes to increased risk of gastric cancer in Chinese population: evidence from a meta-analysis. Tumour Biol. 2013;34:1691–7.CrossRefPubMedGoogle Scholar
  10. 10.
    Dong LM, Potter JD, White E, Ulrich CM, Cardon LR, Peters U. Genetic susceptibility to cancer: the role of polymorphisms in candidate genes. JAMA. 2008;299:2423–36.CrossRefPubMedPubMedCentralGoogle Scholar
  11. 11.
    Cheng YJ, Chien YC, Hildesheim A, Hsu MM, Chen IH, Chuang J, et al. No association between genetic polymorphisms of CYP1A1, GSTM1, GSTT1, GSTP1, NAT2, and nasopharyngeal carcinoma in Taiwan. Cancer Epidemiol Biomarkers Prev. 2003;12:179–80.PubMedGoogle Scholar
  12. 12.
    Deng ZL, Wei YP. Ma Y: [Frequent genetic deletion of detoxifying enzyme GSTM1 and GSTT1 genes in nasopharyngeal carcinoma patients in Guangxi Province, China]. Zhonghua Zhong Liu Za Zhi. 2004;26:598–600.PubMedGoogle Scholar
  13. 13.
    Guo X, O'Brien SJ, Zeng Y, Nelson GW, Winkler CA. GSTM1 and GSTT1 gene deletions and the risk for nasopharyngeal carcinoma in Han Chinese. Cancer Epidemiol Biomarkers Prev. 2008;17:1760–3.CrossRefPubMedGoogle Scholar
  14. 14.
    Jiang Y, Li N, Dong P, Zhang N, Sun Y, Han M, et al. Polymorphisms in GSTM1, GSTTI and GSTP1 and nasopharyngeal cancer in the east of China: a case–control study. Asian Pac J Cancer Prev. 2011;12:3097–100.PubMedGoogle Scholar
  15. 15.
    Wei YP, Long XD, Liu Z, Deng Z. Genetic polymorphism of glutathione-S-transferase m1 and T1 in associated with carcinogenesis of hepatocellular carcinoma and nasopharyngeal carcinoma. Chin-Ger J Clin Oncol. 2012;11:138–41.CrossRefGoogle Scholar
  16. 16.
    Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ. 2003;327:557–60.CrossRefPubMedPubMedCentralGoogle Scholar
  17. 17.
    Mantel N, Haenszel W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst. 1959;22:719–48.PubMedGoogle Scholar
  18. 18.
    DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials. 1986;7:177–88.CrossRefPubMedGoogle Scholar
  19. 19.
    Muellerleile P, Mullen B. Sufficiency and stability of evidence for public health interventions using cumulative meta-analysis. Am J Public Health. 2006;96:515–22.CrossRefPubMedPubMedCentralGoogle Scholar
  20. 20.
    Liu ZG, Wei YP, Ma Y, Deng ZL. Population with gstt1 gene deletion and the relationship to nasopharyngeal carcinoma from Guangxi. Journal of Guangxi Medical University. 2003;20:161–3.Google Scholar
  21. 21.
    Liao ZL, Deng Z, Wei Y, Xie KS, Zhang B. GSTT1, GSTM1 gene deletion polymorphisms and nasopharyngeal carcinoma pathogenesis. Journal of Guangxi Medical University. 2005;22:372–4.Google Scholar
  22. 22.
    Tian SZ, Chen FJ: The analysis of clinical factors related to laryngeal carcinoma and research of the association between genetic polymorphisms of xenobiotic-metabolizing enzymes, DNA repair genes and susceptibility to laryngeal carcinoma. Wanfang Doctoral Dissertation 2007; Zhongshan University:2007.Google Scholar
  23. 23.
    Zhuo XL, Cai L, Xiang ZL, Zhuo WL, Wang Y, Zhang XY. Tp53 codon 72 polymorphism contributes to nasopharyngeal cancer susceptibility: a meta-analysis. Arch Med Res. 2009;40:299–305.CrossRefPubMedGoogle Scholar
  24. 24.
    Huang GL, Guo HQ, Yu CY, Liu XY, Li BB, Wu JJ, et al. XRCC1 polymorphisms and risk of nasopharyngeal carcinoma: a meta-analysis. Asian Pac J Cancer Prev. 2011;12:2329–33.PubMedGoogle Scholar
  25. 25.
    Sharma R, Yang Y, Sharma A, Awasthi S, Awasthi YC. Antioxidant role of glutathione S-transferases: protection against oxidant toxicity and regulation of stress-mediated apoptosis. Antioxid Redox Signal. 2004;6:289–300.CrossRefPubMedGoogle Scholar

Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2013

Authors and Affiliations

  • Bin Jin
    • 1
  • Pin Dong
    • 1
  • Keyong Li
    • 1
  • Bin Shen
    • 1
  • Jin Xie
    • 1
  1. 1.Department of Otolaryngology and Head and Neck SurgeryAffiliated First People’s Hospital of Shanghai Jiaotong UniversityShanghaiChina

Personalised recommendations