Tumor Biology

, Volume 35, Issue 1, pp 93–102 | Cite as

TaqI polymorphism of VDR gene contributes to breast cancer risk

  • Hua Wang
  • Wenjian Wang
  • Dongjie Yang
  • Shenming Wang
Research Article

Abstract

Previous studies on the association of Vitamin D receptor (VDR) TaqI gene polymorphism with breast carcinogenesis have yielded inconsistent and inconclusive findings. The current meta-analysis was performed to provide a more precise assessment on the role of VDR TaqI polymorphism in breast cancer risk. 20 eligible case–control studies involving 9,055 cases and 10,516 controls were identified after a comprehensive literature search of the PubMed, Embase, Web of Science, and Wanfang databases. The pooled odds ratio (OR) with corresponding 95 % confidence interval (95 % CI) was calculated. Stratified analyses by ethnicity and study quality were conducted for further estimation. All statistical analyses were conducted by use of STATA (STATA Corporation, College Station, TX, Version 11.0). The overall ORs showed that the variant t allele and tt genotype were related to an increased risk of breast cancer (ORt vs. T = 1.05, 95 % CI 1.01–1.10, P OR = 0.025; ORtt vs. TT = 1.12, 95 % CI 1.03–1.23, P OR = 0.011; ORtt vs. Tt + TT = 1.10, 95 % CI 1.01–1.20, P OR = 0.023). Stratified analyses of studies in Caucasians and with high-quality further confirmed the results. However, no significant relationship was observed among Asians. This meta-analysis suggests that the VDR TaqI polymorphism confers risk effect on the breast cancer development, particularly in Caucasians.

Keywords

Breast cancer Vitamin D receptor TaqI Polymorphisms Meta-analysis 

Notes

Acknowledgments

This work was supported by the Provincial Natural Science Foundation (S2012040006956).

Conflict of interests

None.

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2013

Authors and Affiliations

  • Hua Wang
    • 1
  • Wenjian Wang
    • 2
  • Dongjie Yang
    • 3
  • Shenming Wang
    • 1
  1. 1.Division of Vascular, Thyroid and Breast Surgery, First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina
  2. 2.Laboratory of Department of Surgery, First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina
  3. 3.Division of Gastrointestinal and Pancreatic Surgery, First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina

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