Elevated expression of hyaluronic acid binding protein 1 (HABP1)/P32/C1QBP is a novel indicator for lymph node and peritoneal metastasis of epithelial ovarian cancer patients
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The present study aims to clarify whether hyaluronan binding protein 1 (HABP1/p32/C1QBP) is an indicator of peritoneal and lymph node metastasis in epithelial ovarian cancer (EOC), which to the authors’ knowledge is not previously reported by others. Western blot analysis demonstrated that HABP1 was highly overexpressed in most metastatic lesions. Of 89 patients whose primary tumors showed high HABP1 expression on immunohistochemical staining, 85 (95.5 %) presented peritoneal metastases and 43 (48.3 %) had lymph node metastases. Univariate and multivariate logistic regression analyses revealed that HABP1 overexpression correlated with peritoneal dissemination and lymph node metastasis in EOC. The specificity and positive predictive value of HABP1 staining were shown to be better for peritoneal metastasis, while the negative and sensitivity predictive value of HABP1 staining were better for lymph node metastasis. The odds ratio of high versus low staining for peritoneal spread was 9.236 (95 % confidence interval (CI), 2.705, 19.316), and that for lymph node metastasis was 8.614 (95 % CI, 2.507, 21.039). Furthermore, HABP1 protein may potentially be used alone or in combination with other markers as a predictive marker of EOC patients with lymph node metastasis and/or peritoneal dissemination.
KeywordsHyaluronan acid binding protein 1 (HABP1) Peritoneal dissemination Lymph node metastasis Epithelial ovarian cancer (EOC)
The authors gratefully acknowledge the financial supports from the Doctoral Research Fund of the Second Affiliated Hospital of Harbin Medical University (Hongyang Yu) and Foundation of Heilongjiang department of education (No. 12531387), Heilongjiang Provincial Health Office (No. 2012–625), and Youth Science Foundation of Heilongjiang Province (No. QC2010078, QC2011C017). We also thank Hui Cheng (The Third Affiliated (Tumor) Hospital of Harbin Medical University) for her IHC assistance.
Conflicts of interest
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