Tumor Biology

, Volume 34, Issue 6, pp 3913–3922 | Cite as

Genetic polymorphisms in glutathione S-transferases P1 (GSTP1) Ile105Val and prostate cancer risk: a systematic review and meta-analysis

  • Qiliang Cai
  • Tao Wu
  • Wei Zhang
  • Xuemei Guo
  • Zhiqun Shang
  • Ning Jiang
  • Jing Tian
  • Yuanjie Niu
Research Article

Abstract

Numerous epidemiological studies have evaluated the association between the glutathione S-transferases P1 (GSTP1) Ile105Val polymorphisms and prostate cancer (PCa) risk. However, these studies have yielded conflicting results. A comprehensive search was conducted through researching MEDLINE, PubMed, Web of Science, and EMBASE, and a total of 13 studies including 3,227 cases and 3,945 controls were identified. A meta-analysis was performed to obtain a summary of estimated odds ratios (ORs) and 95 % confidence intervals (CIs) of GSTP1 polymorphisms for PCa, with attention to study quality and publication bias. The GSTP1 Ile158Val variant genotypes are less associated with increased risk of PCa for the homozygote model (Val/Val vs Ile/Ile: OR = 1.42; I 2= 63.7 %; 95 % CI = 1.02–1.97) and the recessive model (OR = 1.41; I 2= 45.5 %; 95 % CI = 1.10–1.80). However, no associations were detected for other genetic models. In the stratified analysis by ethnicity, significant associations between GSTP1 Ile105Val polymorphism and PCa risk were also found among Caucasians for Val/Val vs Ile/Ile comparison (OR = 1.22; I 2= 0.0 %; 95 % CI = 1.02–1.47) and for the recessive model (OR = 1.26; I 2= 0.0 %; 95 % CI = 1.06–1.49), while there were no associations found for other genetic models. However, no associations were found in Asians and African-Americans for all genetic models when stratified by ethnicity. In conclusion, our meta-analysis provides evidence that GSTP1 Ile105Val gene polymorphisms contributed to PCa susceptibility.

Keywords

GSTP1 polymorphism Ile105Val PCa Meta-analysis Molecular epidemiology 

Notes

Acknowledgments

We thank all authors of the primary studies included in our meta-analyses.

Conflicts of interest

None.

References

  1. 1.
    Hsing AW, Tsao L, Devesa SS. International trends and patterns of PCa incidence and mortality. Int J Cancer. 2000;85:60–7.PubMedCrossRefGoogle Scholar
  2. 2.
    Jemal A, Siegel R, Xu J, Ward E. Cancer statistics. CA Cancer J Clin. 2010;60:277–300.PubMedCrossRefGoogle Scholar
  3. 3.
    Siegel R, Ward E, Brawley O, Jemal A. Cancer statistics. CA Cancer J Clin. 2011;61:212–36.PubMedCrossRefGoogle Scholar
  4. 4.
    Bostwick DG, Burke HB, Djakiew D, Euling S, et al. Human prostate cancer risk factors. Cancer. 2004;101:2371–490.PubMedCrossRefGoogle Scholar
  5. 5.
    Fleshner NE, Klotz LH. Diet, androgens, oxidative stress and prostate cancer susceptibility. Cancer Metastasis Rev. 1998;17:325–30.PubMedCrossRefGoogle Scholar
  6. 6.
    Abate-Shen C, Shen MM. Molecular genetics of prostate cancer. Genes Dev. 2000;14:2410–34.PubMedCrossRefGoogle Scholar
  7. 7.
    Miyake H, Hara I, Kamidono S, Eto H. Oxidative DNA damage in patients with prostate cancer and its response to treatment. J Urol. 2004;171:1533–6.PubMedCrossRefGoogle Scholar
  8. 8.
    Waris G, Ahsan H. Reactive oxygen species: role in the development of cancer and various chronic conditions. J Carcinog. 2006;5:14.PubMedCrossRefGoogle Scholar
  9. 9.
    Choi JY, Neuhouser ML, Barnett M, Hudson M, et al. Polymorphisms in oxidative stress-related genes are not associated with prostate cancer risk in heavy smokers. Cancer Epidemiol Biomark Prev. 2007;16:1115–20.CrossRefGoogle Scholar
  10. 10.
    Nebert DW, Vasiliou V. Analysis of the glutathione S-transferase (GST) gene family. Hum Genomics. 2004;1:460–4.PubMedCrossRefGoogle Scholar
  11. 11.
    Rebbeck TR. Molecular epidemiology of human glutathione S-transferase genotypes GSTM1 and GSTT1 in cancer susceptibility. Cancer Epidemiol Biomark Prev. 1997;6:733–43.Google Scholar
  12. 12.
    Zimniak P, Nanduri B, Pikula S, Bandorowicz-Pikula J, et al. Naturally occurring human glutathione S-transferase GSTP1-1 isoforms with isoleucine and valine in position 104 differ in enzymic properties. Eur J Biochem. 1994;224:893–9.PubMedCrossRefGoogle Scholar
  13. 13.
    Henderson CJ, McLaren AW, Moffat GJ, Bacon EJ, et al. π-class glutathione S-transferase: regulation and function. Chem Biol Interact. 1998;111–112: 69–82.Google Scholar
  14. 14.
    Ryberg D, Skaug V, Hewer A, Phillips DH, et al. Genotypes of glutathione transferase M1 and P1 and their significance for lung DNA adduct levels and cancer risk. Carcinogenesis. 1997;18:1285–9.PubMedCrossRefGoogle Scholar
  15. 15.
    Burim RV, Canalle R, Martinelli AL, Takahashi CS. Polymorphisms in glutathione S-transferases GSTM1, GSTT1 and GSTP1 and cytochromes P450 CYP2E1 and CYP1A1 and susceptibility to cirrhosis or pancreatitis in alcoholics. Mutagenesis. 2004;19:291–8.PubMedCrossRefGoogle Scholar
  16. 16.
    Ntais C, Polycarpo A, Ioannidis JP. Association of GSTM1, GSTT1, and GSTP1 gene polymorphisms with the risk of prostate cancer: a meta-analysis. Cancer Epidemiol Biomark Prev. 2005;14:176–81.Google Scholar
  17. 17.
    Debes JD, Yokomizo A, McDonnell SK, Hebbring SJ, Christensen GB, Cunningham JM, et al. Glutathione-S-transferase P1 polymorphism I105V in familial and sporadic prostate cancer. Cancer Genet Cytogenet. 2004;155:82–6.PubMedCrossRefGoogle Scholar
  18. 18.
    Komiya Y, Tsukino H, Nakao H, Kuroda Y, Imai H, Katoh T. Human glutathione S-transferase A1, T1, M1, and P1 polymorphisms and susceptibility to prostate cancer in the Japanese population. J Cancer Res Clin Oncol. 2005;131:238–42.PubMedCrossRefGoogle Scholar
  19. 19.
    Kidd LC, Woodson K, Taylor PR, Albanes D, Virtamo J, Tangrea JA. Polymorphisms in glutathione-S-transferase genes (GST-M1, GST-T1 and GST-P1) and susceptibility to prostate cancer among male smokers of the ATBC cancer prevention study. Eur J Cancer Prev. 2003;12:317–20.PubMedCrossRefGoogle Scholar
  20. 20.
    Medeiros R, Vasconcelos A, Costa S, Pinto D, Ferreira P, Lobo F, et al. Metabolic susceptibility genes and prostate cancer risk in a southern European population: the role of glutathione S-transferases GSTM1, GSTM3, and GSTT1genetic polymorphisms. Prostate. 2004;58:414–20.PubMedCrossRefGoogle Scholar
  21. 21.
    Wadelius M, Autrup JL, Stubbins MJ, Andersson SO, Johansson JE, Wadelius C, et al. Polymorphisms in NAT2, CYP2D6, CYP2C19 and GSTP1 and their association with prostate cancer. Pharmacogenetics. 1999;9:333–40.PubMedCrossRefGoogle Scholar
  22. 22.
    Kote-Jarai Z, Easton D, Edwards SM, Jefferies S, Durocher F, Jackson RA, et al. Relationship between glutathione S-transferase M1, P1 and T1 polymorphisms and early onset prostate cancer. Pharmacogenetics. 2001;11:325–30.PubMedCrossRefGoogle Scholar
  23. 23.
    Jeronimo C, Varzim G, Henrique R, Oliveira J, Bento MJ, Silva C, et al. I105V polymorphism and promoter methylation of the GSTP1 gene in prostate adenocarcinoma. Cancer Epidemiol Biomark Prev. 2002;11:445–50.Google Scholar
  24. 24.
    Agalliu I, Langeberg WJ, Lampe JW, Salinas CA, Stanford JL. Glutathione S-transferase M1, T1, and P1 polymorphisms and PCa risk in middle-aged men. Prostate. 2006;66:146–56.PubMedCrossRefGoogle Scholar
  25. 25.
    Lavender NA, Benford ML, VanCleave TT, Brock GN, Kittles RA, Moore JH, et al. Examination of polymorphic glutathione S-transferase (GST) genes, tobacco smoking and PCa risk among men of African descent: a case–control study. BMC Cancer. 2009;9:397.PubMedCrossRefGoogle Scholar
  26. 26.
    Sivoňová M, Waczulíková I, Dobrota D, Matáková T, Hatok J, Račay P, et al. Polymorphisms of glutathione-S-transferase M1, T1, P1 and the risk of PCa: a case–control study. J Exp Clin Cancer Res. 2009;28:32–40.PubMedCrossRefGoogle Scholar
  27. 27.
    Ansari SB, Vasudevan R, Bakhshi A, Mirinargesi M, Patimah I, Sabariah AR, et al. Analysis of glutathione S-transferase (M1, T1 and P1) gene polymorphisms in Iranian prostate cancer subjects. Afr J Biotechnol. 2010;9(43):7230–5.Google Scholar
  28. 28.
    Steinbrecher A, Rohrmann S, Timofeeva M, Risch A, Jansen E, Linseisen J. Dietary glucosinolate intake, polymorphisms in selected biotransformation enzymes, and risk of prostate cancer. Cancer Epidemiol Biomark Prev. 2010;19:135–43.CrossRefGoogle Scholar
  29. 29.
    Safarinejad MR, Shafiei N, Safarinejad SH. Glutathione S-transferase gene polymorphisms (GSTM1, GSTT1, GSTP1) and PCa: a case–control study in Tehran, Iran. PCa Prostatic Dis. 2011;14:105–13.CrossRefGoogle Scholar
  30. 30.
    Kwon DD, Lee JW, Han DY, IlY S, Park SC, Jeong HJ, et al. Relationship between the glutathione-S-transferase P1, M1, and T1 genotypes and PCa risk in Korean subjects. Kor J Urol. 2011;52:247–52.CrossRefGoogle Scholar
  31. 31.
    Qadri Q, Sameer AS, Shah ZA, Hamid A, Alam S, Manzoor S, et al. Genetic polymorphism of the glutathione-S-transferase P1 gene (GSTP1) and susceptibility to prostate cancer in the Kashmiri population. Genet Mol Res. 2011;10(4):3038–45.PubMedCrossRefGoogle Scholar
  32. 32.
    Mo ZN, Gao Y, Cao YF, Gao F, Jian LJ. An updating meta-analysis of the GSTM1, GSTT1, and GSTP1 polymorphisms and prostate cancer: a HuGE review. Prostate. 2009;69:662–88.PubMedCrossRefGoogle Scholar
  33. 33.
    Mittal RD, Kesarwani P, Singh R, Ahirwar D, Mandhani A. GSTM1, GSTM3 and GSTT1 gene variants and risk of benign prostate hyperplasia in North India. Dis Markers. 2009;26:85–91.PubMedCrossRefGoogle Scholar
  34. 34.
    Konwar R, Manchanda PK, Chaudhary P, Nayak VL, Singh V, Bid HK. Glutathione S-transferase gene variants and risk of benign prostate hyperplasia in a North Indian population. Asian Pac J Cancer Prev. 2010;11(2):365–70.PubMedGoogle Scholar
  35. 35.
    Konwar R, Manchanda PK, Chaudhary P, Nayak VL, Singh V, Bid HK. Glutathione S-transferase (GST) gene variants and risk of benign prostatic hyperplasia: a report in a North Indian population. Asian Pac J Cancer Prev. 2010;11(4):1067–72.PubMedGoogle Scholar
  36. 36.
    Cochran WG. The combination of estimates from different experiments. Bio-metrics. 1954;10:101–29.Google Scholar
  37. 37.
    Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ. 2003;327:557–60.PubMedCrossRefGoogle Scholar
  38. 38.
    Lau J, Ioannidis JP, Schmid CH. Quantitative synthesis in systematic reviews. Ann Intern Med. 1997;127:820–6.PubMedCrossRefGoogle Scholar
  39. 39.
    Egger M, Smith DG, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997;315:629–34.PubMedCrossRefGoogle Scholar
  40. 40.
    Zintzaras E, Chatzoulis DZ, Karabatsas CH, Stefanidis I. The relationship between C677T methylenetetrahydrofolate reductase gene polymorphism and retinopathy in type 2 diabetes: a meta-analysis. J Hum Genet. 2005;50:267–75.PubMedCrossRefGoogle Scholar
  41. 41.
    Begg CB, Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics. 1994;50:1088–101.PubMedCrossRefGoogle Scholar

Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2013

Authors and Affiliations

  • Qiliang Cai
    • 1
  • Tao Wu
    • 1
  • Wei Zhang
    • 2
  • Xuemei Guo
    • 3
  • Zhiqun Shang
    • 1
  • Ning Jiang
    • 1
  • Jing Tian
    • 1
  • Yuanjie Niu
    • 1
  1. 1.Department of UrologyThe Second Hospital of Tianjin Medical University, Tianjin Institute of UrologyTianjinChina
  2. 2.The Second Hospital of Tianjin Medical UniversityTianjinChina
  3. 3.Tianjin Medical UniversityTianjinChina

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