Tumor Biology

, Volume 34, Issue 6, pp 3913–3922 | Cite as

Genetic polymorphisms in glutathione S-transferases P1 (GSTP1) Ile105Val and prostate cancer risk: a systematic review and meta-analysis

  • Qiliang Cai
  • Tao Wu
  • Wei Zhang
  • Xuemei Guo
  • Zhiqun Shang
  • Ning Jiang
  • Jing Tian
  • Yuanjie Niu
Research Article


Numerous epidemiological studies have evaluated the association between the glutathione S-transferases P1 (GSTP1) Ile105Val polymorphisms and prostate cancer (PCa) risk. However, these studies have yielded conflicting results. A comprehensive search was conducted through researching MEDLINE, PubMed, Web of Science, and EMBASE, and a total of 13 studies including 3,227 cases and 3,945 controls were identified. A meta-analysis was performed to obtain a summary of estimated odds ratios (ORs) and 95 % confidence intervals (CIs) of GSTP1 polymorphisms for PCa, with attention to study quality and publication bias. The GSTP1 Ile158Val variant genotypes are less associated with increased risk of PCa for the homozygote model (Val/Val vs Ile/Ile: OR = 1.42; I 2= 63.7 %; 95 % CI = 1.02–1.97) and the recessive model (OR = 1.41; I 2= 45.5 %; 95 % CI = 1.10–1.80). However, no associations were detected for other genetic models. In the stratified analysis by ethnicity, significant associations between GSTP1 Ile105Val polymorphism and PCa risk were also found among Caucasians for Val/Val vs Ile/Ile comparison (OR = 1.22; I 2= 0.0 %; 95 % CI = 1.02–1.47) and for the recessive model (OR = 1.26; I 2= 0.0 %; 95 % CI = 1.06–1.49), while there were no associations found for other genetic models. However, no associations were found in Asians and African-Americans for all genetic models when stratified by ethnicity. In conclusion, our meta-analysis provides evidence that GSTP1 Ile105Val gene polymorphisms contributed to PCa susceptibility.


GSTP1 polymorphism Ile105Val PCa Meta-analysis Molecular epidemiology 



We thank all authors of the primary studies included in our meta-analyses.

Conflicts of interest



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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2013

Authors and Affiliations

  • Qiliang Cai
    • 1
  • Tao Wu
    • 1
  • Wei Zhang
    • 2
  • Xuemei Guo
    • 3
  • Zhiqun Shang
    • 1
  • Ning Jiang
    • 1
  • Jing Tian
    • 1
  • Yuanjie Niu
    • 1
  1. 1.Department of UrologyThe Second Hospital of Tianjin Medical University, Tianjin Institute of UrologyTianjinChina
  2. 2.The Second Hospital of Tianjin Medical UniversityTianjinChina
  3. 3.Tianjin Medical UniversityTianjinChina

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