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Tumor Biology

, Volume 34, Issue 6, pp 3893–3899 | Cite as

RACK1 promoted the growth and migration of the cancer cells in the progression of esophageal squamous cell carcinoma

  • Fengqing Hu
  • Zhen Tao
  • Mingsong Wang
  • Guoqing Li
  • Yunjiao Zhang
  • Hong Zhong
  • Haibo Xiao
  • Xiao Xie
  • Mei Ju
Research Article

Abstract

Dysregulation of hedgehog signaling has been involved in esophageal squamous cell carcinoma (ESCC) by the mechanisms that are not fully understood. The receptor for activated protein kinase C (RACK1) is involved in the progression of multiple cancers. However, its expression and function in ESCC have not been investigated. Here, we found that the expression of RACK1 was upregulated in ESCC clinical samples. Moreover, over-expression of RACK1 in ESCC cells promoted cell proliferation and migration, while downregulation of RACK1 impaired the proliferation and migration of ESCC cells in vitro and in vivo. Mechanistically, RACK1 promoted the proliferation and migration of ESCC cells by activating hedgehog signaling. Taken together, our study suggested RACK1 might be an important therapeutic target in ESCC.

Keywords

RACK1 ESCC Hedgehog signaling Proliferation Migration 

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2013

Authors and Affiliations

  • Fengqing Hu
    • 1
  • Zhen Tao
    • 2
  • Mingsong Wang
    • 1
  • Guoqing Li
    • 1
  • Yunjiao Zhang
    • 1
  • Hong Zhong
    • 1
  • Haibo Xiao
    • 1
  • Xiao Xie
    • 1
  • Mei Ju
    • 1
  1. 1.Department of Cardiothoracic Surgery, Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina
  2. 2.Department of NeurologyGeneral Hospital of Jinan Military CommandJinanChina

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