Tumor Biology

, Volume 34, Issue 6, pp 3887–3892 | Cite as

Quantitative assessment of the relationship between p21 Ser31Arg polymorphism and cervical cancer

  • Yingchun Ma
  • Yanwei Zhang
  • Li Lin
  • Xiumin Guo
  • Yu Wu
  • Wenjuan Wen
  • Fengli Li
  • Peishu Liu
Research Article


Though many studies were published to assess the relationship between p21 Ser31Arg polymorphism and cervical cancer, there was no definite conclusion on this association. To provide a quantitative assessment of the relationship between p21 Ser31Arg polymorphism and cervical cancer, we performed a meta-analysis of 10 eligible studies (1,539 cases and 2,161 controls). All those 10 studies were from Asians. The odds ratios (OR) with 95 % confidence intervals (95 %CIs) were used to assess the strength of the association, and the pooled ORs were calculated for the codominant model (ArgArg vs. SerSer), the dominant model (ArgArg/SerArg vs. SerSer), and the recessive model (ArgArg vs. SerSer/SerArg). Meta-analysis of those 10 studies showed that there was no association between p21 Ser31Arg polymorphism and cervical cancer risk in Asians under all three models (ArgArg vs. SerSer: OR = 1.04, 95 %CI 0.66–1.65, P = 0.86, I 2 = 78 %; ArgArg/SerArg vs. SerSer: OR = 0.93, 95 %CI 0.66–1.30, P = 0.66, I 2 = 81 %; ArgArg vs. SerSer/SerArg: OR = 1.20, 95 %CI 0.84–1.73, P = 0.32, I 2 = 72 %). Sensitivity analysis performed by omitting each study in turn showed that the pooled results were stable. In summary, there is no association between p21 Ser31Arg polymorphism and cervical cancer risk in Asians. Further studies are needed to assess the possible association between p21 Ser31Arg polymorphism and cervical cancer risk in Caucasians.


p21 Polymorphism Cervical cancer Meta-analysis 


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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2013

Authors and Affiliations

  • Yingchun Ma
    • 1
    • 2
  • Yanwei Zhang
    • 3
  • Li Lin
    • 2
  • Xiumin Guo
    • 2
  • Yu Wu
    • 2
  • Wenjuan Wen
    • 4
  • Fengli Li
    • 2
  • Peishu Liu
    • 1
  1. 1.Department of Gynecology and Obstetrics, Qilu HospitalShandong UniversityJinanPeople’s Republic of China
  2. 2.Department of Obstetrics and GynecologyLiaocheng People’s Hospital and Liaocheng Clinical School of Taishan Medical UniversityLiaochengPeople’s Republic of China
  3. 3.Department of AnesthesiologyLiaocheng People’s Hospital and Liaocheng Clinical School of Taishan Medical UniversityLiaochengPeople’s Republic of China
  4. 4.Department of PathologyLiaocheng People’s Hospital and Liaocheng Clinical School of Taishan Medical UniversityLiaochengPeople’s Republic of China

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