Advertisement

Tumor Biology

, Volume 34, Issue 6, pp 3681–3685 | Cite as

Assessment of the association between XRCC1 Arg399Gln polymorphism and lung cancer in Chinese

  • Yi Li
  • Yi Huang
  • Yu-Shu Cao
  • Jia Zeng
  • Wan-Ning Tong
  • Shi-Lin Xu
  • An-Shan Zhuo
Research Article

Abstract

X-ray repair cross-complementing group 1 (XRCC1) is one of the major DNA repair proteins involved in the base excision repair and plays an important role in the maintenance of genomic integrity. Polymorphisms in XRCC1 may alter the function and repair capacity of XRCC1 protein which further results in the genetic instability and lung carcinogenesis. Previous studies investigating the relationship between XRCC1 Arg399Gln polymorphism and lung cancer risk in Chinese yielded contradictory results. A meta-analysis was performed to clarify the effect of XRCC1 Arg399Gln polymorphism on lung cancer. The association was assessed by calculating the pooled odds ratio (OR) with 95 % confidence intervals (95 %CI). Nineteen studies with a total of 12,835 participants were included into this meta-analysis. Overall, there was an obvious association between XRCC1 Arg399Gln polymorphism and increased risk of lung cancer under three genetic models (Gln vs. Arg: OR = 1.13, 95 %CI 1.01–1.25, P = 0.029; GlnGln vs. ArArg: OR = 1.41, 95 %CI 1.07–1.84, P = 0.013; GlnGln vs. ArArg/ArgGln: OR = 1.37, 95 %CI 1.07–1.76, P = 0.013). Meta-analysis of 18 studies with high quality also found that there was an obvious association between XRCC1 Arg399Gln polymorphism and increased risk of lung cancer under three genetic models. There was no obvious risk of bias in the meta-analysis. Data from the current meta-analysis support the obvious association between XRCC1 Arg399Gln polymorphism and increased risk of lung cancer in Chinese.

Keywords

XRCC1 Arg399Gln Polymorphism Lung cancer 

Notes

Conflicts of interest

None

References

  1. 1.
    Wen C, Dehnel T. China wrestles with lung cancer. Lancet Oncol. 2011;12:15.PubMedCrossRefGoogle Scholar
  2. 2.
    She J, Yang P, Hong Q, Bai C. Lung cancer in China: challenges and interventions. Chest. 2013;143:1117–26.PubMedCrossRefGoogle Scholar
  3. 3.
    Herbst RS, Heymach JV, Lippman SM. Lung cancer. N Engl J Med. 2008;359:1367–80.PubMedCrossRefGoogle Scholar
  4. 4.
    Brennan P, Hainaut P, Boffetta P. Genetics of lung-cancer susceptibility. Lancet Oncol. 2011;12:399–408.PubMedCrossRefGoogle Scholar
  5. 5.
    Hao B, Wang H, Zhou K, Li Y, Chen X, Zhou G, et al. Identification of genetic variants in base excision repair pathway and their associations with risk of esophageal squamous cell carcinoma. Cancer Res. 2004;64:4378–84.PubMedCrossRefGoogle Scholar
  6. 6.
    Ginsberg G, Angle K, Guyton K, Sonawane B. Polymorphism in the DNA repair enzyme xrcc1: utility of current database and implications for human health risk assessment. Mutat Res. 2011;727:1–15.PubMedCrossRefGoogle Scholar
  7. 7.
    Hoeijmakers JH. DNA damage, aging, and cancer. N Engl J Med. 2009;361:1475–85.PubMedCrossRefGoogle Scholar
  8. 8.
    Negrini S, Gorgoulis VG, Halazonetis TD. Genomic instability—an evolving hallmark of cancer. Nat Rev Mol Cell Biol. 2010;11:220–8.PubMedCrossRefGoogle Scholar
  9. 9.
    Bristow RG, Hill RP. Hypoxia and metabolism. Hypoxia, DNA repair and genetic instability. Nat Rev Cancer. 2008;8:180–92.PubMedCrossRefGoogle Scholar
  10. 10.
    Chen S, Tang D, Xue K, Xu L, Ma G, Hsu Y, et al. DNA repair gene xrcc1 and xpd polymorphisms and risk of lung cancer in a Chinese population. Carcinogenesis. 2002;23:1321–5.PubMedCrossRefGoogle Scholar
  11. 11.
    Hu Z, Ma H, Lu D, Zhou J, Chen Y, Xu L, et al. A promoter polymorphism (-77t>c) of DNA repair gene xrcc1 is associated with risk of lung cancer in relation to tobacco smoking. Pharmacogenet Genomics. 2005;15:457–63.PubMedCrossRefGoogle Scholar
  12. 12.
    Shen M, Berndt SI, Rothman N, Mumford JL, He X, Yeager M, et al. Polymorphisms in the DNA base excision repair genes apex1 and xrcc1 and lung cancer risk in Xuan Wei, China. Anticancer Res. 2005;25:537–42.PubMedGoogle Scholar
  13. 13.
    Zhang X, Miao X, Liang G, Hao B, Wang Y, Tan W, et al. Polymorphisms in DNA base excision repair genes adprt and xrcc1 and risk of lung cancer. Cancer Res. 2005;65:722–6.PubMedGoogle Scholar
  14. 14.
    Yin J, Vogel U, Ma Y, Qi R, Sun Z, Wang H. The DNA repair gene xrcc1 and genetic susceptibility of lung cancer in a northeastern Chinese population. Lung Cancer. 2007;56:153–60.PubMedCrossRefGoogle Scholar
  15. 15.
    Li M, Yin Z, Guan P, Li X, Cui Z, Zhang J, et al. Xrcc1 polymorphisms, cooking oil fume and lung cancer in Chinese women nonsmokers. Lung Cancer. 2008;62:145–51.PubMedCrossRefGoogle Scholar
  16. 16.
    Yin J, Vogel U, Ma Y, Qi R, Wang H. Association of DNA repair gene xrcc1 and lung cancer susceptibility among nonsmoking Chinese women. Cancer Genet Cytogenet. 2009;188:26–31.PubMedCrossRefGoogle Scholar
  17. 17.
    Li Z, Guan W, Li MX, Zhong ZY, Qian CY, Yang XQ, et al. Genetic polymorphism of DNA base-excision repair genes (ape1, ogg1 and xrcc1) and their correlation with risk of lung cancer in a Chinese population. Arch Med Res. 2011;42:226–34.PubMedCrossRefGoogle Scholar
  18. 18.
    Qian B, Zhang H, Zhang L, Zhou X, Yu H, Chen K. Association of genetic polymorphisms in DNA repair pathway genes with non-small cell lung cancer risk. Lung Cancer. 2011;73:138–46.PubMedCrossRefGoogle Scholar
  19. 19.
    Guo S, Li X, Gao M, Li Y, Song B, Niu W. The relationship between xrcc1 and xrcc3 gene polymorphisms and lung cancer risk in northeastern Chinese. PLoS One. 2013;8:e56213.PubMedCrossRefGoogle Scholar
  20. 20.
    Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ. 2003;327:557–60.PubMedCrossRefGoogle Scholar
  21. 21.
    DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials. 1986;7:177–88.PubMedCrossRefGoogle Scholar
  22. 22.
    Mantel N, Haenszel W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst. 1959;22:719–48.PubMedGoogle Scholar
  23. 23.
    Song Y, Yi L, Pu Y, Liang G, Cui H. Relationship between polymorphisms of DNA repair gene xrcc1 and susceptibility to lung cancer in Nanjing population [article in Chinese]. J Environ Occup Med. 2004;21:18–21.Google Scholar
  24. 24.
    Li J, Mu L, Wei G, Chen C, Zhang Z, Yu S, et al. Relationship between polymorphisms of DNA repair gene xrcc1 and susceptibility to lung cancer [article in Chinese]. China Oncol. 2005;15:335–8.Google Scholar
  25. 25.
    Li M, Cui Z, He Q, Zhou B. Association of genetic polymorphism in the DNA repair gene xrcc1 with susceptibility to lung cancer in non-smoking women [article in Chinese]. Chin J Oncol. 2005;27:713–6.Google Scholar
  26. 26.
    Li MC, Cui ZS, He QC, Zhou BS. Association of genetic polymorphism in the DNA repair gene xrcc1 with susceptibility to lung cancer in non-smoking women. Zhonghua Zhong Liu Za Zhi. 2005;27:713–6.PubMedGoogle Scholar
  27. 27.
    Zhang W, Wu Y, Wu Y. Study on polymorphism of xrcc 1 and susceptibility to lung cancer [article in Chinese]. Chin J Publ Health. 2005;21:561–3.Google Scholar
  28. 28.
    Hao B, Miao X, Li Y, Zhang X, Sun T, Liang G, et al. A novel t-77c polymorphism in DNA repair gene xrcc1 contributes to diminished promoter activity and increased risk of non-small cell lung cancer. Oncogene. 2006;25:3613–20.PubMedCrossRefGoogle Scholar
  29. 29.
    Yu H, Zeng X, Qiu X, Xu S, Shi L, Zhang X, et al. Polymorphisms in the DNA repair gene xrcc1 and susceptibility to human lung cancer [article in Chinese]. J Guangxi Med Univ. 2006;23:355–8.Google Scholar
  30. 30.
    Su J, Niu R, Liu L, Han X, Shi J. Regression analysis between polymorphisms of DNA repair gene xrcc1 and susceptibility to lung cancer of nonsmoking women [article in Chinese]. J Zhengzhou Univ (Med Sci). 2008;43:234–8.Google Scholar
  31. 31.
    Wang N, Wu YJ, Zhou XL, Wu YM. The polymorphisms of xrcc1 gene and susceptibility to pulmonary cancer. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2012;30:41–4.PubMedGoogle Scholar
  32. 32.
    Liu C, Yin Q, Hu J, Li L, Zhang Y, Wang Y. A meta-analysis of evidences on xpc polymorphisms and lung cancer susceptibility. Tumour Biol. 2013;34:1205–13.PubMedCrossRefGoogle Scholar
  33. 33.
    Wang S, Zhu J, Zhang R, Gu Z. Association between microsomal epoxide hydrolase 1 t113c polymorphism and susceptibility to lung cancer. Tumour Biol. 2013;34:1045–52.PubMedCrossRefGoogle Scholar
  34. 34.
    Dai L, Duan F, Wang P, Song C, Wang K, Zhang J. Xrcc1 gene polymorphisms and lung cancer susceptibility: a meta-analysis of 44 case–control studies. Mol Biol Rep. 2012;39:9535–47.PubMedCrossRefGoogle Scholar
  35. 35.
    Wu J, Liu J, Zhou Y, Ying J, Zou H, Guo S, et al. Predictive value of xrcc1 gene polymorphisms on platinum-based chemotherapy in advanced non-small cell lung cancer patients: a systematic review and meta-analysis. Clin Cancer Res. 2012;18:3972–81.PubMedCrossRefGoogle Scholar

Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2013

Authors and Affiliations

  • Yi Li
    • 1
  • Yi Huang
    • 2
  • Yu-Shu Cao
    • 1
  • Jia Zeng
    • 1
  • Wan-Ning Tong
    • 1
  • Shi-Lin Xu
    • 1
  • An-Shan Zhuo
    • 1
  1. 1.Department of Respiratory Medicine, the 411th Hospital of PLAShanghaiChina
  2. 2.Department of Respiratory Medicine, Changhai HospitalSecond Military Medical UniversityShanghaiChina

Personalised recommendations