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Tumor Biology

, Volume 34, Issue 5, pp 2469–2476 | Cite as

A comparative overview of general risk factors associated with the incidence of colorectal cancer

  • Sabha Rasool
  • Showkat Ahmad Kadla
  • Vamiq Rasool
  • Bashir Ahmad Ganai
Review

Abstract

Cancers found in colorectal region remain largely localized to the large intestine and rectum. They are derived from the epithelium and are considered to be among the most frequently detected cancers. They are known to occur in approximately 5 % population of the Western world. After metastasis, a patient’s 5-year postsurgical survival chances unfortunately fall from 90 to 10 % or even less. Adenocarcinoma, the most common cell type of colon cancer, alone constitutes 95 % of the cases. Lymphoma and squamous cell carcinoma can also be found in some cases. Because 5 % of persons are predisposed to development of colorectal cancer, this disease has often been addressed as an important public health issue. Factors that are known in particular to increase a person’s risk to develop this cancer are as follows: an individual’s age, dietary habits, any complaint of obesity, diabetes, previous history of cancer or intestinal polyps, personal habit of alcohol consumption and smoking, family history of colon cancer, race, sex, and ethnicity. Since the risk of colorectal cancer is increasing steadily in Kashmir, India, like in some other corners of Asia, exhaustive efforts are being made to find the association of above given and other risk factors with the development of this gastrointestinal tract cancer. Adoption of Western life style, diet mimicry, together with a habit of having physically inactive life style and consumption of red meat in particular can be blamed as being active players to a considerable extent.

Keywords

CRC Risk factors Incidence of CRC Age-standardized incidence rate 

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2013

Authors and Affiliations

  • Sabha Rasool
    • 1
  • Showkat Ahmad Kadla
    • 2
  • Vamiq Rasool
    • 3
  • Bashir Ahmad Ganai
    • 1
    • 4
  1. 1.Department of BiochemistryUniversity of KashmirSrinagarIndia
  2. 2.Division of Gastroeneterology, Department of MedicineGovernment Medical College SrinagarSrinagarIndia
  3. 3.Department of pediatricsGovernment Medical CollegeSrinagarIndia
  4. 4.Department of Biochemistry and Clinical BiochemistryUniversity of KashmirKashmirIndia

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