Tumor Biology

, Volume 34, Issue 5, pp 3077–3082 | Cite as

The associations between the polymorphisms of the ER-α gene and the risk of uterine leiomyoma (ULM)

  • Yi Feng
  • Xiaojuan Lin
  • Shengtao Zhou
  • Ning Xu
  • Tao Yi
  • Xia Zhao
Research Article


The ER-α gene polymorphisms have been reported to be associated with uterine leiomyoma (ULM) risk. The purpose of the present study was to perform a meta-analysis to explore the polymorphisms in the ER-α gene and the risk of ULM. A comprehensive search for relevant articles was conducted in MEDLINE (Ovid), PubMed, Embase, Springer, EBSCO, Web of Science, CNKI, Wanfang, Weipu, and Google Scholar. A total of nine articles were identified. Among the nine articles, 11 cohorts reported the PvuII polymorphism and six reported the XbaI polymorphism. The strength of the relationships between the polymorphisms in ER-α (PvuII and XbaI) and the risk of ULM was assessed by odds ratios (ORs). The studies provided overall OR estimates for PvuII and XbaI, leading to a pooled OR of 1.41 (PP+Pp vs. pp: OR = 1.41, 95 % confidence interval (95 %CI) = 1.02–1.96, P = 0.04), 1.13 (XX+Xx vs. xx: OR = 1.13, 95 %CI = 0.91–1.41, P = 0.25), respectively. The PvuII polymorphism in the ER-α gene may be a risk factor for ULM. Future studies are needed to validate our conclusions.


Uterine leiomyoma ER-α gene Meta-analysis Polymorphism 



This research was supported by the Specialized Research Fund for the Doctoral Program of Higher Education (No.20120181120054).

Conflicts of interest



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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2013

Authors and Affiliations

  • Yi Feng
    • 1
  • Xiaojuan Lin
    • 1
  • Shengtao Zhou
    • 1
  • Ning Xu
    • 1
  • Tao Yi
    • 1
  • Xia Zhao
    • 1
    • 2
  1. 1.Department of Gynecology and Obstetrics, Key Laboratory of Obstetrics and Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second HospitalSichuan UniversityChengduPeople’s Republic of China
  2. 2.The State Key Laboratory of Biotherapy, West China HospitalSichuan UniversityChengduPeople’s Republic of China

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