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Tumor Biology

, Volume 34, Issue 5, pp 2753–2757 | Cite as

Significant association between Nijmegen breakage syndrome 1 657del5 polymorphism and breast cancer risk

Research Article

Abstract

Many studies were published to evaluate the association between Nijmegen breakage syndrome 1 (NBS1) 657del5 polymorphism and breast cancer risk, but the results remained inconsistent. To derive a more precise estimation on the possible association, we performed a meta-analysis of previous published studies. Case–control studies on the association between NBS1 657del5 polymorphisms and breast cancer risk were included into this meta-analysis. We used the odds ratio (OR) with 95 % confidence interval (95 % CI) to assess the strength of the association. Ten studies with a total of 25,365 subjects were identified and included into this meta-analysis. Meta-analysis of those ten studies showed that there was a significant association between NBS1 657del5 polymorphisms and breast cancer risk (pooled OR = 2.66, 95 % CI 1.82–3.90, P < 0.001). The cumulative meta-analyses showed a trend of a more significant association between NBS1 657del5 polymorphisms and breast cancer risk as data accumulated by publication year. Thus, our meta-analysis suggests that there was a significant association between NBS1 657del5 polymorphisms and breast cancer risk, and NBS1 657del5 polymorphism results in an increased risk of breast cancer.

Keywords

Nijmegen breakage syndrome 1 Polymorphism Breast cancer Meta-analysis 

Notes

Conflicts of interest

None of the authors have any conflict of interests to declare.

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2013

Authors and Affiliations

  • Guofeng Zhang
    • 1
  • Yu Zeng
    • 2
  • Zhongyan Liu
    • 1
  • Weiwei Wei
    • 1
  1. 1.Department of General Surgery, Tongji HospitalTongji University School of MedicineShanghaiChina
  2. 2.Department of Pathology, Tongji HospitalTongji University School of MedicineShanghaiChina

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