Tumor Biology

, Volume 34, Issue 5, pp 2659–2664 | Cite as

XRCC1 polymorphisms increase bladder cancer risk in Asians: a meta-analysis

  • Fei Zhang
  • Jian-Hong Wu
  • Wei Zhao
  • Hai-Tao Liu
Research Article


X-ray cross complementing group 1 (XRCC1) polymorphisms and bladder cancer risk has been investigated for years, but the result in Asian population is till inconclusive. Thus, we performed this meta-analysis to determine the association of XRCC1 Arg194Trp, Arg280His, and Arg399Gln polymorphisms with bladder cancer risk in the Asian population. PubMed, EMBASE, and China National Knowledge Infrastructure were searched up to January 2013 to identify eligible studies. The association strength was measured with odd ratios (ORs) and 95 % confidence intervals (95 % CIs). A total of nine eligible studies, including 1,931 bladder cancer patients and 2,192 controls, were identified. Significant increased risk of bladder cancer was observed for Arg194Trp polymorphism (allele comparison OR = 1.20, 95 % CI: 1.06–1.36, Pheterogeneity = 0.11; dominant model OR = 1.20, 95 % CI: 1.02–1.41, Pheterogeneity = 0.37) and Arg280His polymorphism (heterozygote comparison OR = 1.87, 95 % CI: 1.21–2.90, Pheterogeneity = 0.01; dominant model OR = 1.75, 95 % CI: 1.05–2.90, Pheterogeneity = 0.01); however, Arg399Gln was not associated with susceptibility to bladder cancer. No evidence of publication bias was detected. Our meta-analysis results suggest that XRCC1 Arg194Trp and Arg280His polymorphisms are associated with significantly increased risk of bladder cancer in Asians.


XRCC1 Polymorphisms Bladder cancer Meta-analysis 



This work was supported by the Shanghai Jiao Tong University Medical and Engineering Collaborative Research Fund Project (YG2012MS45).

Conflict of interest

The authors declare that they have no conflict of interest.

Supplementary material

13277_2013_816_MOESM1_ESM.doc (120 kb)
ESM 1 (DOC 120 kb)


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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2013

Authors and Affiliations

  • Fei Zhang
    • 1
  • Jian-Hong Wu
    • 1
  • Wei Zhao
    • 1
  • Hai-Tao Liu
    • 1
  1. 1.Department of UrologyShanghai Jiaotong University Affiliated Shanghai First People’s HospitalShanghaiPeople’s Republic of China

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