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Tumor Biology

, Volume 34, Issue 5, pp 2625–2631 | Cite as

The difference in clinic-pathological features between signet ring cell carcinoma and gastric mucinous adenocarcinoma

  • Hao Jiang
  • Hongfeng Zhang
  • Lantian Tian
  • Xi Zhang
  • Yingwei Xue
Research Article

Abstract

We investigated the clinical and pathological features as well as the prognosis of signet ring cell carcinoma (SRC) and gastric mucinous carcinoma (GMC) to lay a foundation for the management of these two diseases. Two thousand four hundred thirty gastric cancer patients, including 288 SRCs and 80 GMCs who had received a gastrectomy between 1997 and 2007, were retrospectively evaluated. There were significant differences in tumor location, distant metastasis status, lymph node dissection, depth of invasion, Borrmann type, pTNM stage, and pathological lymph node status between SRCs and GMC (P = 0.001, 0.003, 0.01, 0.0002, 0.0013, 0.0001, and 0.265, respectively). After prognostic analysis, the cases with GMC received a relatively low 5-year specific survival rate compared to SRC (58.68 % vs. 66.25 %; P = 0.064). After Cox regression analysis, gender, age, lymph node metastatic ratio, pTNM stage, curative operation, and distant metastasis were identified as the independent prognostic factors in SRC. On the other hand, pTNM stage and distant metastasis were identified as the independent prognostic factors in GMC. In conclusion, the clinical and pathological features as well as prognosis of GMC and gastric SRC differed. Therefore, the treatment of the two diseases should be individualized.

Keywords

Gastric tumor SRC GMC Prognosis 

Notes

Conflicts of interest

None

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2013

Authors and Affiliations

  • Hao Jiang
    • 1
  • Hongfeng Zhang
    • 1
  • Lantian Tian
    • 2
  • Xi Zhang
    • 1
  • Yingwei Xue
    • 1
  1. 1.Department of Gastrointestinal Surgerythe Third Affiliated Hospital of Harbin Medical UniversityHarbinChina
  2. 2.Department of General Surgerythe First Affiliated Hospital of Harbin Medical UniversityHarbinChina

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