Tumor Biology

, Volume 34, Issue 5, pp 2611–2615 | Cite as

X-ray repair cross-complementing group 1 Arg194Trp polymorphism is associated with increased risk of lung cancer in Chinese Han population

  • Tao Wu
  • Yun-hua Xu
  • Xiao-lei Ye
Research Article


There were many studies performed to assess the association between X-ray repair cross-complementing group 1 (XRCC1) Arg194Trp polymorphism and lung cancer risk in Chinese Han population, but contradictory results were reported. To provide a comprehensive and objective assessment of the association, a meta-analysis of all eligible case–control studies was carried out. After searching the databases and reading the abstracts, 12 case–control studies on the association between XRCC1 Arg194Trp polymorphism and lung cancer risk were finally included into this meta-analysis. Those 12 studies included a total of 4,385 cases and 4,545 controls. XRCC1 Arg194Trp polymorphism was associated with increased risk of lung cancer in Chinese Han population under three main models (allele contrast model, odds ratio (OR) = 1.12, 95 % confidence interval (CI) 1.00–1.26, P = 0.049; homozygote model, OR = 1.27, 95 % CI 1.09–1.48, P = 0.003; recessive model, OR = 1.26, 95 % CI 1.09–1.46, P = 0.003). However, there was no obvious association between XRCC1 Arg194Trp polymorphism and lung cancer risk under the dominant model (OR = 1.06, 95 % CI 0.98–1.16, P = 0.146). Sensitivity analysis suggested the stability and liability of this meta-analysis. Therefore, this meta-analysis suggests that XRCC1 Arg194Trp polymorphism is associated with increased risk of lung cancer in Chinese Han population.


XRCC1 Arg194Trp Lung cancer Chinese Han population Meta-analysis 



This study is funded by the following funds: (1) the National Natural Sciences Foundation of China (project for young scientists, no. 30800999) and (2) project supported by the Zhejiang Provincial Natural Science Foundation of China (no. Y2080374).

Conflicts of interest



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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2013

Authors and Affiliations

  1. 1.Department of Cardiology, The First Affiliated Hospital, College of MedicineZhejiang UniversityHangzhouPeople’s Republic of China
  2. 2.Shanghai Lung Tumor Clinic Medical CenterShanghai Chest Hospital Affiliated to Shanghai Jiao Tong UniversityShanghaiChina
  3. 3.Ningbo Institute of Medical SciencesNingboChina

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