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Tumor Biology

, Volume 34, Issue 5, pp 2611–2615 | Cite as

X-ray repair cross-complementing group 1 Arg194Trp polymorphism is associated with increased risk of lung cancer in Chinese Han population

Research Article

Abstract

There were many studies performed to assess the association between X-ray repair cross-complementing group 1 (XRCC1) Arg194Trp polymorphism and lung cancer risk in Chinese Han population, but contradictory results were reported. To provide a comprehensive and objective assessment of the association, a meta-analysis of all eligible case–control studies was carried out. After searching the databases and reading the abstracts, 12 case–control studies on the association between XRCC1 Arg194Trp polymorphism and lung cancer risk were finally included into this meta-analysis. Those 12 studies included a total of 4,385 cases and 4,545 controls. XRCC1 Arg194Trp polymorphism was associated with increased risk of lung cancer in Chinese Han population under three main models (allele contrast model, odds ratio (OR) = 1.12, 95 % confidence interval (CI) 1.00–1.26, P = 0.049; homozygote model, OR = 1.27, 95 % CI 1.09–1.48, P = 0.003; recessive model, OR = 1.26, 95 % CI 1.09–1.46, P = 0.003). However, there was no obvious association between XRCC1 Arg194Trp polymorphism and lung cancer risk under the dominant model (OR = 1.06, 95 % CI 0.98–1.16, P = 0.146). Sensitivity analysis suggested the stability and liability of this meta-analysis. Therefore, this meta-analysis suggests that XRCC1 Arg194Trp polymorphism is associated with increased risk of lung cancer in Chinese Han population.

Keywords

XRCC1 Arg194Trp Lung cancer Chinese Han population Meta-analysis 

Notes

Acknowledgments

This study is funded by the following funds: (1) the National Natural Sciences Foundation of China (project for young scientists, no. 30800999) and (2) project supported by the Zhejiang Provincial Natural Science Foundation of China (no. Y2080374).

Conflicts of interest

None.

References

  1. 1.
    Herbst RS, Heymach JV, Lippman SM. Lung Cancer. N Engl J Med. 2008;359:1367–80.CrossRefPubMedGoogle Scholar
  2. 2.
    Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin. 2011;61:69–90.CrossRefPubMedGoogle Scholar
  3. 3.
    Chen WQ. Estimation of cancer incidence and mortality in china in 2004–2005. Chin J Oncol. 2009;31:664–8.Google Scholar
  4. 4.
    Brennan P, Hainaut P, Boffetta P. Genetics of lung-cancer susceptibility. Lancet Oncol. 2011;12:399–408.CrossRefPubMedGoogle Scholar
  5. 5.
    Dong LM, Potter JD, White E, Ulrich CM, Cardon LR, Peters U. Genetic susceptibility to cancer: the role of polymorphisms in candidate genes. JAMA. 2008;299:2423–36.PubMedCentralCrossRefPubMedGoogle Scholar
  6. 6.
    Ang MK, Patel MR, Yin XY, Sundaram S, Fritchie K, Zhao N, et al. High XRCC1 protein expression is associated with poorer survival in patients with head and neck squamous cell carcinoma. Clin Cancer Res. 2011;17:6542–52.PubMedCentralCrossRefPubMedGoogle Scholar
  7. 7.
    Simsek D, Furda A, Gao Y, Artus J, Brunet E, Hadjantonakis AK, et al. Crucial role for DNA ligase III in mitochondria but not in XRCC1-dependent repair. Nature. 2011;471:245–8.PubMedCentralCrossRefPubMedGoogle Scholar
  8. 8.
    Berquist BR, Singh DK, Fan J, Kim D, Gillenwater E, Kulkarni A, et al. Functional capacity of XRCC1 protein variants identified in DNA repair-deficient Chinese hamster ovary cell lines and the human population. Nucleic Acids Res. 2010;38:5023–35.PubMedCentralCrossRefPubMedGoogle Scholar
  9. 9.
    Ginsberg G, Angle K, Guyton K, Sonawane B. Polymorphism in the DNA repair enzyme XRCC1: utility of current database and implications for human health risk assessment. Mutat Res. 2011;727:1–15.CrossRefPubMedGoogle Scholar
  10. 10.
    Guo S, Li X, Gao M, Li Y, Song B, Niu W. The relationship between XRCC1 and XRCC3 gene polymorphisms and lung cancer risk in northeastern Chinese. PLoS One. 2013;8:e56213.PubMedCentralCrossRefPubMedGoogle Scholar
  11. 11.
    Yin J, Vogel U, Ma Y, Qi R, Wang H. Association of DNA repair gene XRCC1 and lung cancer susceptibility among nonsmoking Chinese women. Cancer Genet Cytogenet. 2009;188:26–31.CrossRefPubMedGoogle Scholar
  12. 12.
    Chang JS, Wrensch MR, Hansen HM, Sison JD, Aldrich MC, Quesenberry Jr CP, et al. Base excision repair genes and risk of lung cancer among San Francisco Bay Area Latinos and African-Americans. Carcinogenesis. 2009;30:78–87.PubMedCentralCrossRefPubMedGoogle Scholar
  13. 13.
    Li M, Yin Z, Guan P, Li X, Cui Z, Zhang J, et al. XRCC1 polymorphisms, cooking oil fume and lung cancer in Chinese women nonsmokers. Lung Cancer. 2008;62:145–51.CrossRefPubMedGoogle Scholar
  14. 14.
    Yin J, Vogel U, Ma Y, Qi R, Sun Z, Wang H. The DNA repair gene XRCC1 and genetic susceptibility of lung cancer in a northeastern Chinese population. Lung Cancer. 2007;56:153–60.CrossRefPubMedGoogle Scholar
  15. 15.
    Hao B, Miao X, Li Y, Zhang X, Sun T, Liang G, et al. A novel T-77C polymorphism in DNA repair gene XRCC1 contributes to diminished promoter activity and increased risk of non-small cell lung cancer. Oncogene. 2006;25:3613–20.CrossRefPubMedGoogle Scholar
  16. 16.
    Shen M, Berndt SI, Rothman N, Mumford JL, He X, Yeager M, et al. Polymorphisms in the DNA base excision repair genes APEX1 and XRCC1 and lung cancer risk in Xuan Wei, China. Anticancer Res. 2005;25:537–42.PubMedGoogle Scholar
  17. 17.
    Hu Z, Ma H, Lu D, Zhou J, Chen Y, Xu L, et al. A promoter polymorphism (−77T > C) of DNA repair gene xrcc1 is associated with risk of lung cancer in relation to tobacco smoking. Pharmacogenet Genomics. 2005;15:457–63.CrossRefPubMedGoogle Scholar
  18. 18.
    Chen S, Tang D, Xue K, Xu L, Ma G, Hsu Y, et al. DNA repair gene XRCC1 and XPD polymorphisms and risk of lung cancer in a Chinese population. Carcinogenesis. 2002;23:1321–5.CrossRefPubMedGoogle Scholar
  19. 19.
    Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ. 2003;327:557–60.PubMedCentralCrossRefPubMedGoogle Scholar
  20. 20.
    Mantel N, Haenszel W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst. 1959;22:719–48.PubMedGoogle Scholar
  21. 21.
    DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials. 1986;7:177–88.CrossRefPubMedGoogle Scholar
  22. 22.
    Zhang WJ, Wu YM, Wu YJ. Study on polymorphism of XRCC 1 and susceptibility to lung cancer. Chin J Public Health. 2005;21:561–3.Google Scholar
  23. 23.
    Su J, Niu RG, Han XY, Shi JP, Liu L, Li JW, et al. Polymorphisms of DNA repair gene XRCC1 codon194 and its susceptibility to lung cancer. Fudan Univ J Med Sci. 2008;35:348–52.Google Scholar
  24. 24.
    Wang N, Wu YJ, Zhou XL, Wu YM: [The polymorphisms of XRCC1 gene and susceptibility to pulmonary cancer]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2012;30:41–44.Google Scholar
  25. 25.
    Xiao XY, Wang XD, Zang DY. Mmp1-1607 1G/2G polymorphism and lung cancer risk: a meta-analysis. Tumour Biol. 2012;33:2385–92.CrossRefPubMedGoogle Scholar
  26. 26.
    Wang S, Zhu J, Zhang R, Gu Z. Association between microsomal epoxide hydrolase 1 T113C polymorphism and susceptibility to lung cancer. Tumour Biol. 2013;34:1045–52.CrossRefPubMedGoogle Scholar
  27. 27.
    Xue H, Ni P, Lin B, Xu H, Huang G. X-ray repair cross-complementing group 1 (XRC1) genetic polymorphisms and gastric cancer risk: a huge review and meta-analysis. Am J Epidemiol. 2011;173:363–75.CrossRefPubMedGoogle Scholar
  28. 28.
    Chen B, Zhou Y, Yang P, Wu XT. Polymorphisms of XRCC1 and gastric cancer susceptibility: a meta-analysis. Mol Biol Rep. 2012;39:1305–13.CrossRefPubMedGoogle Scholar
  29. 29.
    Li Y, Liu F, Tan SQ, Wang Y, Li SW. X-ray repair cross-complementing group 1 (XRC1) genetic polymorphisms and cervical cancer risk: a huge systematic review and meta-analysis. PLoS One. 2012;7:e44441.PubMedCentralCrossRefPubMedGoogle Scholar

Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2013

Authors and Affiliations

  1. 1.Department of Cardiology, The First Affiliated Hospital, College of MedicineZhejiang UniversityHangzhouPeople’s Republic of China
  2. 2.Shanghai Lung Tumor Clinic Medical CenterShanghai Chest Hospital Affiliated to Shanghai Jiao Tong UniversityShanghaiChina
  3. 3.Ningbo Institute of Medical SciencesNingboChina

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