Tumor Biology

, Volume 34, Issue 4, pp 2403–2407 | Cite as

Glutathione S-transferase M1 null genotype contributes to increased risk of esophageal carcinoma in Chinese population

  • Shan Zhong
  • Wei Zhao
  • Chaojing Lu
  • Bailing Li
  • Yang Yuan
  • Danfeng Guo
  • Zhijie Chang
  • Binhua Jiao
  • Lixin Yang
Research Article

Abstract

Glutathione S-transferases (GSTs) play important roles in the detoxification of electrophilic carcinogens, and GSTM1 null genotype is associated with the dysfunction of GSTs. Previous studies investigating the association between GSTM1 null genotype and risk of esophageal carcinoma in Chinese provided inconsistent findings. To provide a more precise estimation on the association between GSTM1 null genotype and risk of esophageal carcinoma in Chinese population, a meta-analysis was performed. Eligible studies were searched in PubMed, Embase, and China National Knowledge Infrastructure databases. Odds ratio (OR) with the corresponding 95 % confidence interval (95 %CI) was used to assess the association. A total of 18 case–control studies involving 1,947 cases and 3,506 controls were finally included in the meta-analysis. Meta-analysis of those 18 studies showed that GSTM1 null genotype was associated with an increased risk of esophageal carcinoma in Chinese (random effect model OR = 1.49, 95 %CI = 1.11–2.00, P = 0.008). The findings from cumulative meta-analysis showed that the association was more obvious as the data increased by publication year. There was no risk of publication bias in the meta-analysis. Therefore, the findings from our meta-analysis provide a strong evidence for the association between GSTM1 null genotype and risk of esophageal carcinoma in Chinese population, and GSTM1 null genotype contributes to increased risk of esophageal carcinoma in Chinese.

Keywords

GSTM1 Esophageal carcinoma Polymorphism Meta-analysis 

Notes

Conflicts of interest

None

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2013

Authors and Affiliations

  • Shan Zhong
    • 1
    • 2
  • Wei Zhao
    • 3
  • Chaojing Lu
    • 4
  • Bailing Li
    • 4
  • Yang Yuan
    • 4
  • Danfeng Guo
    • 5
  • Zhijie Chang
    • 1
  • Binhua Jiao
    • 2
  • Lixin Yang
    • 4
  1. 1.Institute of Biomedicine and School of MedicineTsinghua UniversityBeijingPeople’s Republic of China
  2. 2.Department of Biochemistry and Molecular BiologySecond Military Medical UniversityShanghaiPeople’s Republic of China
  3. 3.Shanghai Food and Drug Packaging Material Control CenterShanghaiPeople’s Republic of China
  4. 4.Department of Cardiothoracic SurgeryChanghai Hospital Second Military Medical UniversityShanghaiPeople’s Republic of China
  5. 5.The Second Detachment of the Chinese People’s Armed Police Force Shanghai CorpsShanghaiPeople’s Republic of China

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