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Tumor Biology

, Volume 34, Issue 4, pp 2275–2281 | Cite as

Peroxiredoxin III protein expression is associated with platinum resistance in epithelial ovarian cancer

Research Article

Abstract

We investigated the association between peroxiredoxin III (PRX III) and chemotherapy resistance in ovarian cancer. Patient’s specimens were taken at the time of surgery. Determination of resistance is based on whether first diagnosis of relapse occurred within 6 months after the cessation of chemotherapy. PRX III expression was immunohistochemically determined in paraffin-embedded specimens from platinum-resistant (Pt-resistant) and platinum-sensitive (Pt-sensitive) patients. The Pt-resistant group had significantly higher PRX III protein compared to the Pt-sensitive group. The two groups showed no significant differences in pathological classification and age, although they differed significantly in tissue differentiation and stage. PRX III protein was significantly higher in the Pt-resistant serous carcinomas, in moderately and poorly differentiated, and in stage III and IV ovarian cancer tissues compared to the Pt-sensitive group. PRX III may be associated with drug resistance in ovarian cancer.

Keywords

PRX III Epithelial ovarian cancer Chemotherapy Immunohistochemistry Cisplatin 

Notes

Conflicts of interest

None

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2013

Authors and Affiliations

  1. 1.Department of Gynecology and ObstetricsShengjing Hospital of China Medical UniversityShenyangChina
  2. 2.Department of Gynecology and ObstetricsBenxi Center Hospital of China Medical UniversityBenxiChina

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