Tumor Biology

, Volume 34, Issue 2, pp 1225–1233 | Cite as

Lack of association between MHTFR Glu429Ala polymorphism and breast cancer susceptibility: a systematic review and meta-analysis of 29 research studies

  • Zhanjiang Jiao
  • Dan Li
Research Article


The association between MHTFR Glu429Val polymorphism and breast cancer risk are inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed. A total of 29 studies including 8,649 cases and 18,672 controls were involved in this meta-analysis. Overall, no significant associations were found between MTHFR Glu429Ala polymorphism and breast cancer risk when all studies were pooled into the meta-analysis (Glu/Glu vs Ala/Ala: OR = 0.891, 95 % CI = 0.782–1.015; Glu/Ala vs Ala/Ala: OR = 0.874, 95 % CI = 0.760–1.006; dominant model: OR = 0.885, 95 % CI = 0.775–1.012; and recessive model: OR = 0.989, 95 % CI = 0.931–1.051). In the subgroup analysis by ethnicity, significantly elevated breast cancer risk was associated with Glu/Glu variant genotype in homozygote comparison and recessive genetic model (Glu/Glu vs Ala/Ala: OR = 0.78, 95 % CI = 0.63–0.97; Glu/Glu vs Glu/Ala: OR = 0.92, 95 % CI = 0.85–0.99; recessive model: OR = 0.91, 95 % CI = 0.85–0.97), while no significant associations were found for all comparison models in other ethnicity populations. In conclusion, this meta-analysis suggests that the MTHFR Glu429Ala polymorphism may be not associated with breast cancer development.


Polymorphism Breast cancer MTFHR Susceptibility Meta-analysis 


Conflicts of interest



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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2013

Authors and Affiliations

  1. 1.Department of Hepatobiliary Surgery, Nanfang HospitalSouthern Medical UniversityGuangzhouChina
  2. 2.Hubei Provincial Corps HospitalChinese People’s Armed Police ForcesWuhanChina

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