RETRACTED ARTICLE: Polymorphisms of excision repair gene XPD Lys751Gln and hOGG1 Ser326Cys might not be associated with hepatocellular carcinoma risk: a meta-analysis
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The xeroderma pigmentosum group D (XPD) and human 8-oxoguanine glycosylase 1 (hOGG1) genes have been suggested to play an important role in the pathogenesis of hepatocellular carcinoma (HCC). However, the results have been inconsistent. In this study, we performed a meta-analysis to clarify the associations of polymorphisms of XPD and hOGG1 genes with HCC risk. Published literature from PubMed, EMBASE, and Chinese National Knowledge Infrastructure were retrieved. Pooled odds ratio (OR) with 95 % confidence interval (CI) was calculated using a fixed- or random-effects model. Seven studies (1,955 HCC cases and 2,023 controls) for XPD Lys751Gln polymorphism and six studies (1,470 HCC cases and 1,541 controls) for hOGG1 Ser326Cys polymorphism were included in the final meta-analysis. For XPD Lys751Gln polymorphism, no significant association was found under all genetic models (Gln/Gln vs Lys/Lys OR = 1.09, 95 % CI = 0.28–4.18; Gln/Lys vs Lys/Lys OR = 1.41, 95 % CI = 0.81–2.44; dominant model OR = 1.40, 95 % CI = 0.77–2.57; recessive model OR = 1.02, 95 % CI = 0.33–3.23). For hOGG1 Ser326Cys polymorphism, there was a significant association of this polymorphism with HCC risk under heterogeneous codominant model (OR = 1.38, 95 % CI = 1.01–1.88) and dominant model (OR = 1.57, 95 % CI = 1.14–2.16). The sensitivity analysis indicated that the significant association between hOGG1 Ser326Cys polymorphism and HCC risk was not robust. The present meta-analysis has limited evidence to support the association of XPD Lys751Gln and hOGG1 Ser326Cys polymorphisms with HCC risk. Further, large-scale studies with the consideration for gene–gene/gene–environment interactions should be conducted to investigate the association.
KeywordsXPD hOGG1 Polymorphism Hepatocellular carcinoma Meta-analysis
The work was funded by the Zhejiang Medicine, Health, and Science (no. 2010KYB127), Zhejiang Province Chinese Medicine Research Program (2012ZA130), and Zhejiang Gong Yi Xing Technology Application Project (2012C33025).
Conflicts of interest
- 4.Shen M, Hung RJ, Brennan P, Malavielle C, Donato F, Placidi D, et al. Polymorphisms of the DNA repair genes XRCC1, XRCC3, XPD, interaction with environmental exposure, and bladder cancer risk in a case–control study in Northern Italy. Cancer Epidemiol Biomark Prev. 2003;12:1234–40.Google Scholar
- 5.Xu L, Wu Y, Jin Y, Yu Y, Qian G. A case–control study on polymorphism of DNA repair gene XPD and susceptibility to hepatocellular carcinoma. Tumor. 2004;24:526–9. in Chinese.Google Scholar
- 7.Xie W. Association between the nucleotide excision repair (NER) genes polymorphisms and genetic susceptibility and clinical phenotype of hepatocellular carcinoma. Doctoral Dissertation of Guangxi Medical University 2007; 1–103. in Chinese.Google Scholar
- 9.Cui X, Su H. A case–control study on the polymorphism of gene XPD and the susceptibility of primary hepatic carcinoma. Med J Chin People’s Health. 2010;22:912–4. in Chinese.Google Scholar
- 10.Gulnaz A, Sayyed AH, Amin F, Khan AU, Aslam MA, Shaikh RS, et al. Association of XRCC1, XRCC3, and XPD genetic polymorphism with an increased risk of hepatocellular carcinoma because of the hepatitis B and C virus. Eur J Gastroenterol Hepatol. 2012. doi: 10.1097/MEG.0b013e328359a775.
- 11.Hu H, Zhang C, Deng W, Huang Q, Dong X, Wang C, et al. Study on the familial aggregation factors of hepatocellular carcinoma. Yiyao Qianyan. 2012;2:143–4. in Chinese.Google Scholar
- 14.Zhang H, Hao B, He F. Studies on association between susceptibility of hepatocellular carcinoma and genetic polymorphism Ser326Cys of DNA repair gene hOGG1. Chin J Clin Oncol. 2005;32:841–3. in Chinese.Google Scholar
- 16.Wang A, Cong W, He X, Jia H, Jin X, Zhu G, et al. A hOGG1 gene polymorphism and genetic susceptibility to colorectal cancer and hepatocellular carcinoma. Chin J Gastroenterol Hepatol. 2008;17:854–7. in Chinese.Google Scholar
- 17.Ji L, Zeng X, Li L, Chou X, Chen S, Yu H. Interaction between the single-nucleotide polymorphism of DNA repair gene hOGG1 and HBV infection and its susceptibility to hepatocellular carcinoma. J Hyg Res. 2011;40:705–8. in Chinese.Google Scholar
- 18.Tang G, Li X, Liu T, Yang J, Luo J, Liang Z. Genetic polymorphisms of DNA repair genes in patients with hepatocellular carcinoma. Shandong Med J. 2011;51:19–20. in Chinese.Google Scholar