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Tumor Biology

, Volume 34, Issue 1, pp 493–504 | Cite as

Adiponectin (ADIPOQ) rs2241766 G/T polymorphism is associated with risk of cancer: evidence from a meta-analysis

  • Wei Zhou
  • Yi Liu
  • De-Wu Zhong
Research Article

Abstract

Associations between adiponectin (ADIPOQ) genetic polymorphisms (rs2241766 G/T and rs266729 G/C) and cancer risk have been extensively studied in the past decade, while conflicting results were reported. Therefore, this study would explore the associations by using a meta-analysis. The databases of Medline, Embase, and Wangfang were retrieved, and the latest updated time was 1 August 2012. Effect sizes of odds ratio and 95 % confidence interval (OR and 95 % CI) were calculated by using a fixed- or random-effect model. A total of 12 studies with 10,368 participants were identified for association between ADIPOQ rs2241766 G/T and risk of cancer, and ten studies with 12,665 participants were for association between ADIPOQ rs266729 G/C and risk of cancer. Overall combined analyses indicated that neither ADIPOQ rs2241766 G/T nor rs266729 G/C was associated with risk of cancer incidence (OR (95 % CI), 0.89 (0.61–1.30) for GG vs. TT and 0.94 (0.83–1.06) for G carriers vs. T carriers for rs2241766 G/T; 0.99 (0.85–1.16) for GG vs. CC and 0.96 (0.87–1.06) for G carriers vs. C carriers for rs266729 G/C). When stratified analyses were conducted according to the participants’ ethnicity, sources of controls, types of cancer, and sample size, we found that G allele of ADIPOQ rs2241766 G/T was significantly associated with decreased risk of cancer based on population-based case–control studies (OR (95 % CI), 0.65 (0.50–0.85) for GG vs. TT and 0.88 (0.79–0.98) for G carriers vs. T carriers). In contrast, there was no association between rs266729 G/C polymorphism and risk of cancer when subgroup analyses were conducted. In summary, this meta-analysis indicated that ADIPOQ rs2241766 G/T rather than rs266729 G/C polymorphism was closely associated with risk of cancer development.

Keywords

Adiponectin Gene polymorphism Cancer Meta-analysis 

Notes

Conflicts of interest

None

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2012

Authors and Affiliations

  1. 1.Department of Hepatobiliary Surgery, The Second Xiangya HospitalCentral South UniversityChangsha CityChina
  2. 2.Department of General SurgeryThe second affiliated hospital of Nan Chang UniversityNanChang CityChina

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