Tumor Biology

, Volume 34, Issue 1, pp 395–401 | Cite as

RETRACTED ARTICLE: The interaction between smoking and GSTM1 variant on lung cancer in the Chinese population

  • Yanan Zhang
  • Chibo Liu
Research Article


Smoking and the deletion of GSTM1 variant are two risk factors of lung cancer. This meta-analysis was performed to examine the GSTM1–smoking interaction on lung cancer in the Chinese population. PubMed, Web of Science, and other Chinese databases were searched to include all the related studies. The number of subjects with two GSTM1 genotypes across different smoking status was extracted. The pooled odds ratios (ORs) with 95 % confidence intervals (CIs) were calculated using fixed- or random-effect model. A total of 4,345 cases and 5,031 controls from 30 studies were included in the meta-analysis. Compared with nonsmokers having power GSTM1, the pooled ORs with 95 % CIs for lung cancer in smokers with power GSTM1, in nonsmokers with null GSTM1, and in smokers with null GSTM1 were 2.24 (1.82–2.76), 1.48 (1.23–1.79), and 4.18 (3.38–5.16), respectively. This meta-analysis showed that there was an interaction between the GSTM1 and smoking on the risk of lung cancer in the Chinese. Further studies are needed to examine the interactions between other environmental factors and GSTM1 on the risk of lung cancer.


GSTM1 Polymorphism Smoking Interaction Lung cancer Meta-analysis 



The work was funded by Zhejiang Medicine, Health, and Science (no.2010KYB127), Zhejiang Province Chinese medicine research program (2012ZA130) and Zhejiang Gong Yi Xing Technology Application Project (No. 2011C33045). The authors also thank the Department of Laboratory Medicine, Taizhou Municipal Hospital for the support.

Conflicts of interest


Supplementary material

13277_2012_562_Fig5_ESM.jpg (166 kb)
Fig. 1

Meta-analysis of OR with 95 % CI for lung cancer by quality score in smokers with power GSTM1 (JPEG 166 kb)

13277_2012_562_MOESM1_ESM.tif (1.2 mb)
High-resolution image (TIFF 1183 kb)
13277_2012_562_Fig6_ESM.jpg (164 kb)
Fig. 2

Meta-analysis of OR with 95 % CI for lung cancer by quality score in nonsmokers with null GSTM1 (JPEG 164 kb)

13277_2012_562_MOESM2_ESM.tif (1.1 mb)
High-resolution image (TIFF 1174 kb)
13277_2012_562_Fig7_ESM.jpg (163 kb)
Fig. 3

Meta-analysis of OR with 95 % CI for lung cancer by quality score in smokers with null GSTM1 (JPEG 163 kb)

13277_2012_562_MOESM3_ESM.tif (1.1 mb)
High-resolution image (TIFF 1166 kb)


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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2012

Authors and Affiliations

  1. 1.Department of Occupational Health and Toxicology, School of Public HealthFudan UniversityShanghaiChina
  2. 2.Department of Clinical Laboratory, Taizhou Municipal HospitalTaizhou UniversityTaizhouChina

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