CANCER STEM CELLS, CIRCULATING TUMOR CELLS
P1.1 Circulating tumor cells as a biomarker for the patients with castration resistant prostate cancer
M. Jančíková1, V. Mikulová1, O. Čapoun2, V, Soukup2, H. Honová3, T. Zima1
1Institute of Medical Biochemistry and Laboratory Diagnostics; 2Department of Urology; 3Department of Oncology, General University Hospital in Prague, First Faculty of Medicine, Charles University in Prague
Background: Castration resistant prostate cancer (CRPC) is an advanced stage of the prostate cancer. Patients suffering from the CRPC exhibit castration levels of testosterone, increasing levels of prostate specific antigen (PSA) and presence of metastases. Circulating tumor cells (CTCs) are rare cells detached from the primary tumor into the blood stream. They are an important part of the metastatic process. The presence of CTCs is thus highly probable in the blood of the patients with CRPC and it may allow us to study the role of CTCs in the metastatic process.