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TUMOR BIOLOGY AND METASTASIS
O1.1 PAR genes (PAR1 & 2): Probes for pathological assessment and targets for therapy
Rachel Bar-Shavit, Arun Kancharla, Mohammad Jaber, Daniel Agranovitch, Myriam Maoz, Bella Maly, Tamar Peretz and Beatrice Uziely
Hadassa-Hebrew University Hospital
Background: Taking the issue of breast tumor categorization a step forward and establish molecular imprints to accompany histopathological assessment is an important and timely task. Mammalian protease- activated receptors (PARs) comprise a family of four genes, uniquely activated by proteolytic cleavage. The central role played by PAR1, and PAR2 in tumor biology is currently emerging. We have identified PAR1 and PAR2 C-tails as scaffold sites for the immobilization of a PH-domain signal protein (e.g., Etk/Bmx) and established the minimal binding region within these tails.
Indeed, a mutant of consecutive A residues inserted into the proposed Etk/Bmx binding region of PAR1 C-tail (e.g., hPar1-7A) abolished...