Tumor Biology

, Volume 34, Issue 1, pp 65–70 | Cite as

The expression of chemokines CCL19, CCL21 and their receptor CCR7 in oral squamous cell carcinoma and its relevance to cervical lymph node metastasis

  • Helenisa Helena Oliveira-Neto
  • Pedro Paulo Chaves de Souza
  • Márcio Roberto Barbosa da Silva
  • Elismauro Francisco Mendonça
  • Tarcília Aparecida Silva
  • Aline Carvalho Batista
Research Article


The purpose of this study is to determine the expression of CCL19, CCL21, and CCR7 in samples of oral squamous cell carcinoma (OSCC) and their relationship with clinical and microscopic parameters. A comparative analysis was made of the mRNA expression of these chemokines and receptor in OSCC and normal oral mucosa. The immunoexpression of CCR7, CCL19, and CCL21 was also verified in OSCC and lymph nodes. Statistical significance was accepted at P < 0.05. Similar levels of CCR7, CCL19, and CCL21 mRNA in OSCC and normal oral mucosa were seen. A low expression of CCL19 and CCL21 in the intra- and peritumoral regions was observed. Scarce CCL19+ and CCL21+ cells were also noted in metastatic and non-metastatic lymph nodes. No association was found between the expression of these chemokines and clinical and microscopic parameters. Our findings would suggest that CCL19 and CCL21 may not be associated with cervical lymph node metastasis or other clinical and microscopic factors in OSCC.


CCL19 CCL21 CCR7 Chemokine Oral squamous cell carcinoma Metastasis Lymph node 



The authors wish to thank the Araújo Jorge Hospital of the Goiás Combat Cancer Association, Goiânia and the Department of Physiology and Pathology, Dental School, São Paulo State University, Araraquara, São Paulo, Brazil. This work was supported by grants from the National Council for Scientific and Technological Development (CNPq) (grants 470951/2009-5 and 554445/2009-3). Drs. Batista, Silva, and Mendonça are CNPq Research Fellows.

Conflicts of interest



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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2012

Authors and Affiliations

  • Helenisa Helena Oliveira-Neto
    • 1
  • Pedro Paulo Chaves de Souza
    • 2
  • Márcio Roberto Barbosa da Silva
    • 3
  • Elismauro Francisco Mendonça
    • 1
  • Tarcília Aparecida Silva
    • 4
  • Aline Carvalho Batista
    • 1
    • 5
  1. 1.Department of Stomatology (Oral Pathology), Dental SchoolFederal University of GoiásGoiâniaBrazil
  2. 2.Department of Physiology and Pathology, Dental SchoolSão Paulo State UniversityAraraquaraBrazil
  3. 3.Division of Head and Neck, Araújo Jorge HospitalGoiás Combat Cancer AssociationGoiâniaBrazil
  4. 4.Department of Oral Surgery and Pathology, Dental SchoolFederal University of Minas GeraisBelo HorizonteBrazil
  5. 5.Disciplina de Patologia Geral e Bucal, Faculdade de OdontologiaUniversidade Federal de GoiásGoiâniaBrazil

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