Skip to main content
SpringerLink
Log in

CYP1A1 Ile462Val polymorphism and cervical cancer: evidence from a meta-analysis

  • Research Article
  • Published:
Tumor Biology

Abstract

Many publications have evaluated the correlation between Cytochrome P450 1A1 (CYP1A1) Ile462Val polymorphism and cervical cancer risk, but the results remain inconclusive. To provide a more robust estimate of this effect, a meta-analysis was carried out. We systematically searched PubMed, Embase and CBM databases for studies published before May 2012. The association between CYP1A1 Ile462Val polymorphism and cervical cancer risk was assessed by calculating pooled odds ratios (OR) with its 95 % confidence intervals (95 % CI). On the basis of our inclusion criteria, ten studies with a total of 2,423 individuals were included in the meta-analysis. Overall, CYP1A1 Ile462Val polymorphism was associated with increased risk of cervical cancer (Val versus Ile, OR = 1.43; 95 % CI, 1.03–1.97; ValVal versus IleIle, OR = 2.43; 95 % CI, 1.19–4.95; ValVal+ValIle versus IleIle, OR = 1.59; 95 % CI, 1.00–2.53). Ethnic subgroup analyses showed a significant association was found in Caucasians (Val versus Ile, OR = 2.03; 95 % CI, 1.17–3.51; ValVal versus IleIle, OR = 2.74; 95 % CI, 1.30–5.75; ValVal+ValIle versus IleIle, OR = 2.50; 95 % CI, 1.33–4.70), but not in Asians. In conclusion, this meta-analysis suggests that CYP1A1 Ile462Val polymorphism plays an important role in susceptibility to cervical cancer. Further studies with large sample size and careful design need performing to identify this association more comprehensively.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin. 2011;61:69–90.

    Article  PubMed  Google Scholar 

  2. Forouzanfar MH, Foreman KJ, Delossantos AM, Lozano R, Lopez AD, Murray CJ, et al. Breast and cervical cancer in 187 countries between 1980 and 2010: a systematic analysis. Lancet. 2011;378:1461–84.

    Article  PubMed  Google Scholar 

  3. Muñoz N, Bosch FX, De Sanjosé S, Herrero R, Castellsagué X, Shah KV, et al. Epidemiologic classification of human papillomavirus types associated with cervical cancer. N Engl J Med. 2003;348:518–27.

    Article  PubMed  Google Scholar 

  4. Schiffman M, Castle PE, Jeronimo J, Rodriguez AC, Wacholder S. Human papillomavirus and cervical cancer. Lancet. 2007;370:890–907.

    Article  PubMed  CAS  Google Scholar 

  5. Nebert DW, Gonzalez FJ. P450 genes: structure, evolution, and regulation. Annu Rev Biochem. 1987;56:945–93.

    Article  PubMed  CAS  Google Scholar 

  6. Nebert DW, Dalton TP. The role of cytochrome p450 enzymes in endogenous signalling pathways and environmental carcinogenesis. Nat Rev Cancer. 2006;6:947–60.

    Article  PubMed  CAS  Google Scholar 

  7. Martucci CP, Fishman J. P450 enzymes of estrogen metabolism. Pharmacol Ther. 1993;57:237–57.

    Article  PubMed  CAS  Google Scholar 

  8. Androutsopoulos VP, Tsatsakis AM, Spandidos DA. Cytochrome p450 cyp1a1: wider roles in cancer progression and prevention. BMC Cancer. 2009;9:187.

    Article  PubMed  Google Scholar 

  9. Persson I, Johansson I, Ingelman-Sundberg M. In vitro kinetics of two human cyp1a1 variant enzymes suggested to be associated with interindividual differences in cancer susceptibility. Biochem Biophys Res Commun. 1997;231:227–30.

    Article  PubMed  CAS  Google Scholar 

  10. Kawajiri K, Nakachi K, Imai K, Yoshii A, Shinoda N, Watanabe J. Identification of genetically high risk individuals to lung cancer by DNA polymorphisms of the cytochrome p450ia1 gene. FEBS Lett. 1990;263:131–3.

    Article  PubMed  CAS  Google Scholar 

  11. Masson LF, Sharp L, Cotton SC, Little J. Cytochrome p-450 1a1 gene polymorphisms and risk of breast cancer: a huge review. Am J Epidemiol. 2005;161:901–15.

    Article  PubMed  CAS  Google Scholar 

  12. Huang M, Chen Q, Xiao J, Zhao X, Liu C. Cyp1a1 ile462val is a risk factor for ovarian cancer development. Cytokine. 2012;58:73–8.

    Article  PubMed  CAS  Google Scholar 

  13. Wang JJ, Zheng Y, Sun L, Wang L, Yu PB, Li HL, et al. Cyp1a1 ile462val polymorphism and susceptibility to lung cancer: a meta-analysis based on 32 studies. Eur J Cancer Prev. 2011;20:445–52.

    Article  PubMed  CAS  Google Scholar 

  14. Gutman G, Morad T, Peleg B, Peretz C, Bar-Am A, Safra T, et al. Cyp1a1 and cyp2d6 gene polymorphisms in Israeli Jewish women with cervical cancer. Int J Gynecol Cancer. 2009;19:1300–2.

    Article  PubMed  Google Scholar 

  15. Huang YK, Hsieh HC, Sun JA, Chao CF, Huang HR, Lai HC, et al. Genetic polymorphisms of phase i and phase ii xenobiotic enzymes in human papillomavirus related lesion and cancer of the uterine cervix. Tzu Chi Med J. 2006;18:267–74.

    CAS  Google Scholar 

  16. Joseph T, Chacko P, Wesley R, Jayaprakash PG, James FV, Pillai MR. Germline genetic polymorphisms of cyp1a1, gstm1 and gstt1 genes in indian cervical cancer: associations with tumor progression, age and human papillomavirus infection. Gynecol Oncol. 2006;101:411–7.

    Article  PubMed  CAS  Google Scholar 

  17. Sugawara T, Nomura E, Sagawa T, Sakuragi N, Fujimoto S. Cyp1a1 polymorphism and risk of gynecological malignancy in Japan. Int J Gynecol Cancer. 2003;13:785–90.

    Article  PubMed  CAS  Google Scholar 

  18. Taskiran C, Aktas D, Yigit-Celik N, Alikasifoglu M, Yuce K, Tuncbilek E, et al. Cyp1a1 gene polymorphism as a risk factor for cervical intraepithelial neoplasia and invasive cervical cancer. Gynecol Oncol. 2006;101:503–6.

    Article  PubMed  CAS  Google Scholar 

  19. Stroup DF, Berlin JA, Morton SC, Olkin I, Williamson GD, Rennie D, et al. Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis of observational studies in epidemiology (moose) group. JAMA. 2000;283:2008–12.

    Article  PubMed  CAS  Google Scholar 

  20. Wells GA, Shea B, O’connell D, Peterson J, Welch V, Losos M, Tugwell P. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. Ottawa, Canada: Dept of Epidemiology and Community Medicine, University of Ottawa. http://www.ohri.ca/programs/clinical_epidemiology/oxford.htm. Accessed 26 April 2012.

  21. Boivin J, Griffiths E, Venetis CA. Emotional distress in infertile women and failure of assisted reproductive technologies: meta-analysis of prospective psychosocial studies. BMJ. 2011;342:d223.

    Article  PubMed  CAS  Google Scholar 

  22. Millett GA, Flores SA, Marks G, Reed JB, Herbst JH. Circumcision status and risk of hiv and sexually transmitted infections among men who have sex with men: a meta-analysis. JAMA. 2008;300:1674–84.

    Article  PubMed  CAS  Google Scholar 

  23. Rohlfs RV, Weir BS. Distributions of Hardy–Weinberg equilibrium test statistics. Genetics. 2008;180:1609–16.

    Article  PubMed  CAS  Google Scholar 

  24. Cochran WG. The combination of estimates from different experiments. Biometrics. 1954;10:101–29.

    Article  Google Scholar 

  25. Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ. 2003;327:557–60.

    Article  PubMed  Google Scholar 

  26. DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials. 1986;7:177–88.

    Article  PubMed  CAS  Google Scholar 

  27. Mantel N, Haenszel W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst. 1959;22:719–48.

    PubMed  CAS  Google Scholar 

  28. Thompson SG, Higgins J. How should meta–regression analyses be undertaken and interpreted? Stat Med. 2002;21:1559–73.

    Article  PubMed  Google Scholar 

  29. Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997;315:629–34.

    Article  PubMed  CAS  Google Scholar 

  30. Ding FY, Ma GF, Song XH, Shi WH, Lan JY, Yu HY. Relationship between cyp1a1 gene polymorphism and genetic susceptibility of cervical carcinoma. Jiangsu Med J. 2011;37:2562–4. Article in Chinese.

    CAS  Google Scholar 

  31. Geng J, Shi YR, Wang H, Qin R. Research of cytochrome p450 i a1 lle/val polymorphism and genetic susceptibility in cervical cancer. J Bengbu Med Coll. 2010;35:762–7. Article in Chinese.

    CAS  Google Scholar 

  32. Shi YR, Geng J, Cheng LQ, Wang H, Zhang Y. Association of cytochrome p450 1a1 gene polymorphisms with cervical cancer. Fudan Univ J Med Sci. 2011;38:428–31. Article in Chinese.

    CAS  Google Scholar 

  33. Zhang SH, Kong AR. Polymorphisms of cyp1a1 gene and hpv infection of cervical squamous carcinoma. Master's thesis of Taishan Medical University; 2009 (Article in Chinese).

  34. Zhang X. P450 1a1 gene polymorphism and cervical cancer ileval correlation. Jilin Med J. 2011;32:419–20. Article in Chinese.

    Google Scholar 

  35. Agorastos T, Papadopoulos N, Lambropoulos AF, Chrisafi S, Mikos T, Goulis DG, et al. Glutathione-s-transferase m1 and t1 and cytochrome p1a1 genetic polymorphisms and susceptibility to cervical intraepithelial neoplasia in Greek women. Eur J Cancer Prev. 2007;16:498–504.

    Article  PubMed  CAS  Google Scholar 

  36. Goodman MT, McDuffie K, Hernandez B, Bertram CC, Wilkens LR, Guo C, et al. Cyp1a1, gstm1, and gstt1 polymorphisms and the risk of cervical squamous intraepithelial lesions in a multiethnic population. Gynecol Oncol. 2001;81:263–9.

    Article  PubMed  CAS  Google Scholar 

  37. Juarez-Cedillo T, Vallejo M, Fragoso JM, Hernandez-Hernandez DM, Rodriguez-Perez JM, Sanchez-Garcia S, et al. The risk of developing cervical cancer in Mexican women is associated to cyp1a1 mspi polymorphism. Eur J Cancer. 2007;43:1590–5.

    Article  PubMed  CAS  Google Scholar 

  38. Kim JW, Lee CG, Park YG, Kim KS, Kim IK, Sohn YW, et al. Combined analysis of germline polymorphisms of p53, gstm1, gstt1, cyp1a1, and cyp2e1: relation to the incidence rate of cervical carcinoma. Cancer. 2000;88:2082–91.

    Article  PubMed  CAS  Google Scholar 

  39. Nishino K, Sekine M, Kodama S, Sudo N, Aoki Y, Seki N, et al. Cigarette smoking and glutathione s-transferase m1 polymorphism associated with risk for uterine cervical cancer. J Obstet Gynaecol Res. 2008;34:994–1001.

    PubMed  CAS  Google Scholar 

  40. von Keyserling H, Bergmann T, Schuetz M, Schiller U, Stanke J, Hoffmann C, et al. Analysis of 4 single-nucleotide polymorphisms in relation to cervical dysplasia and cancer development using a high-throughput ligation-detection reaction procedure. Int J Gynecol Cancer. 2011;21:1664–71.

    Article  Google Scholar 

  41. Ioannidis JP, Patsopoulos NA, Evangelou E. Uncertainty in heterogeneity estimates in meta-analyses. BMJ. 2007;335:914–6.

    Article  PubMed  Google Scholar 

  42. Sergentanis TN, Economopoulos KP, Choussein S, Vlahos NF. Cytochrome p450 1a1 (cyp1a1) gene polymorphisms and cervical cancer risk: a meta-analysis. Mol Biol Rep. 2012;39:6647–54.

    Article  PubMed  CAS  Google Scholar 

  43. Sergentanis TN, Economopoulos KP, Choussein S, Vlahos NF. Cytochrome p450 1a1 gene polymorphisms and endometrial cancer risk: a meta-analysis. Int J Gynecol Cancer. 2011;21:323–31.

    Article  PubMed  Google Scholar 

  44. Guo R, Guo X. Quantitative assessment of the associations between CYP1A1 polymorphisms and gastric cancer risk. Tumour Biol. 2012; 33(4):1125–32

    Google Scholar 

  45. Yu L, Sun L, Jiang YF, Lu BL, Sun DR, Zhu LY. Interactions between cyp1a1 polymorphisms and cigarette smoking are associated with the risk of hepatocellular carcinoma: evidence from epidemiological studies. Mol Biol Rep. 2012;39:6641–6.

    Article  PubMed  CAS  Google Scholar 

  46. Peters J, Mengersen K. Selective reporting of adjusted estimates in observational epidemiology studies: reasons and implications for meta-analyses. Eval Health Prof. 2008;31:370–89.

    Article  PubMed  Google Scholar 

Download references

Conflicts of interest

None

Author information

Authors and Affiliations

  1. Department of Gynecology and Obstetrics, Fourth Affiliated Hospital, Harbin Medical University, Harbin, 150001, China

    Shuyan Yang, Changru Jia, Hong Zhu & Shiyu Han

Authors
  1. Shuyan Yang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Changru Jia
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Hong Zhu
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Shiyu Han
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Shiyu Han.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Yang, S., Jia, C., Zhu, H. et al. CYP1A1 Ile462Val polymorphism and cervical cancer: evidence from a meta-analysis. Tumor Biol. 33, 2265–2272 (2012). https://doi.org/10.1007/s13277-012-0488-y

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13277-012-0488-y

Keywords

Search

Navigation