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Tumor Biology

, Volume 33, Issue 6, pp 1973–1981 | Cite as

RETRACTED ARTICLE: Glutathione S-transferase P1 gene Ile105Val polymorphism might be associated with lung cancer risk in the Chinese Han population

  • Xiaogang Chen
  • Liying Liang
  • Xiao Hu
  • Yu Chen
Research Article

Abstract

Genetic variations in glutathione S-transferase P1 (GSTP1) gene have been suggested to be involved in the development of cancer. However, the results from the studies regarding the association between GSTP1 Ile105Val polymorphism and lung cancer risk in the Chinese population have been inconsistent. Thus, we conducted a meta-analysis to investigate the association. Published literature from PubMed, Chinese Biomedical Literature Database, Chinese Wanfang Data, and Chinese National Knowledge Infrastructure databases were searched for eligible publications. Pooled odds ratios (ORs) with 95 % confidence intervals (CIs) were calculated using random or fixed effect model. Ten studies (1,506 cases/1,714 controls) were included in the meta-analysis. The results suggested that GSTP1 Ile105Val polymorphism was marginally associated with lung cancer risk in the Chinese Han population under a multiplicative model (G vs. A, odds ratio (OR) = 1.22, 95 % confidence interval = 1.02–1.46), under a homogeneous codominant model (GG vs. AA, OR = 1.67, 95 % CI = 1.14–2.45), under a heterogeneous codominant model (GA vs. AA, OR = 1.15, 95 % CI = 0.98–1.35), under a dominant model (GG + GA vs. AA, OR = 1.21, 95 % CI = 1.04–1.39), and under a recessive model (GG vs. GA + AA, OR = 1.59, 95 % CI = 1.09–2.31), respectively. Moreover, after adjusted for age, gender, and smoking status, the significant association under dominant model remained (OR = 1.27, 95 % CI = 1.07–1.51). This meta-analysis suggested that there might be an association between GSTP1 Ile105Val polymorphism and lung cancer in the Chinese Han population.

Keywords

GSTP1 Genetic polymorphism Meta-analysis Lung cancer 

Notes

Conflicts of interest

None

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2012

Authors and Affiliations

  1. 1.Department of laboratory Medicine, First Affiliated Hospital, School of MedicineZhejiang UniversityHangzhouChina
  2. 2.School Hospital (Huajiachi)Zhejiang UniversityHangzhouChina

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