Tumor Biology

, Volume 33, Issue 5, pp 1719–1725 | Cite as

Expression and association of HER2 with prognosis in early-stage (T1–T2N0M0) non-small cell lung cancer

  • Qing Xia
  • Zhihua Zhu
  • Jian Wang
  • Dongrong Situ
  • Ningning Zhou
  • Wenqi Jang
Research Article


The expression of human epidermal growth factor receptor 2 (HER2) is related to tumor progression in many human malignancies. This study evaluated the significance of HER2 in early-stage non-small cell lung cancer (NSCLC). Specimens were obtained from 172 patients with early-stage (T1–T2N0M0) NSCLC, which included T1N0M0 (n = 52) and T2N0M0 (n = 120). The expression of HER2 was determined by immunohistochemistry (IHC). HER2 expression and its relationship with clinicopathological parameters and survival were analyzed. The expression of HER2 was significantly higher in the non-squamous cell carcinoma than in the squamous cell carcinoma (74.3 % vs. 53.7 %, p = 0.008). HER2 expression and tumor size were independent prognostic indicators in the multivariate analysis (p = 0.007 and p = 0.015, respectively). Expression of HER2 indicated a worse 5-year overall survival (65 % vs. 86 %, p = 0.014), especially for stages IB and IIA diseases (p = 0.035 and p = 0.043, respectively) and adenocarcinoma (p = 0.047). Therefore, HER2 may be related with the pathogenesis of NSCLC and act as an unfavorable prognostic factor in T1N0M0 and T2N0M0 NSCLC, especially in stages IB and IIA diseases.


Non-small cell lung cancer Prognosis HER2 Immunohistochemistry 



Human epidermal growth factor receptor 2


Non-small cell lung cancer




Receiver operating characteristic


Overall survival


Area under the ROC curve


Overall response rate


Time to progression



This study was supported by the Fundamental Research Funds for the Central Universities and the grant from Youth Training Plan of Sun Yat-Sen University (No. 10ykpy38), the Research Award Fund for Outstanding Young Researchers in Sun Yat-Sen Cancer Center (Nos. 303045172006 and 303045172005), the National Natural Science Foundation of China (No. 30901728) and the Science & Technology Pillar Program of Guangdong Province (No. 2011B031800220). The authors declare their independence of sponsors, and the content of this article has not been influenced by the sponsors.

Conflicts of interest



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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2012

Authors and Affiliations

  1. 1.State Key Laboratory of Oncology in South China, Department of Medical OncologySun Yat-Sen University Cancer CenterGuangzhouChina
  2. 2.State Key Laboratory of Oncology in South China, Department of Thoracic OncologySun Yat-Sen University Cancer CenterGuangzhouChina
  3. 3.State Key Laboratory of Oncology in South China, Department of AnesthesiaSun Yat-Sen University Cancer CenterGuangzhouChina

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