Tumor Biology

, Volume 33, Issue 5, pp 1467–1476 | Cite as

Cyclin D1 G870A polymorphism and lung cancer risk: a meta-analysis

  • Jianming Liu
  • Qiande Liao
  • Yangde Zhang
  • Shenghua Sun
  • Caigao Zhong
  • Xinmin Liu
Research Article


Many studies have investigated the association between Cyclin D1 (CCND1) G870A polymorphism and lung cancer risk, but the impact of CCND G870A polymorphism on lung cancer is unclear owing to the obvious inconsistence among those studies. This study aimed to quantify the strength of association between CCND1 G870A polymorphism and lung cancer risk. We searched the PubMed, Embase, and Wangfang databases for articles on studies relating the CCND1 G870A polymorphism to the risk of lung cancer in humans. We estimated summary odds ratios (ORs) with their confidence intervals (CIs) to assess the association. Meta-analyses of total studies showed that CCND1 G870A polymorphism was associated with lung cancer risk under three genetic models (ORA versus G = 1.13, 95 % CI 1.03–1.24; ORAA versus GG = 1.20, 95 % CI 1.07–1.35; ORAA versus AG + GG = 1.23, 95 % CI 1.02–1.50). Meta-analyses of studies with high quality showed that CCND1 G870A polymorphism was associated with lung cancer risk under two genetic models (ORA versus G = 1.08, 95 % CI 1.02–1.15; ORAA versus GG = 1.17, 95 % CI 1.04–1.32). Subgroup analyses by ethnicity and sensitivity analyses further identified the significant association above. No evidence of publication bias was observed. Meta-analyses of available data show a significant association between the CCND1 G870A polymorphism and lung cancer risk, and CCND1 G870A polymorphic variant A contributes to increased risk of lung cancer.


Cyclin D1 Lung cancer Gene polymorphism Meta-analysis 



We thank Fei Zhang, Xiangya Hospital of Changsha, for her statistical support.


No external funding was either sought or obtained for this study.

Conflicts of interest



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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2012

Authors and Affiliations

  • Jianming Liu
    • 1
    • 2
  • Qiande Liao
    • 2
  • Yangde Zhang
    • 2
  • Shenghua Sun
    • 1
  • Caigao Zhong
    • 3
  • Xinmin Liu
    • 3
  1. 1.Department of Respiratory diseasesthe Third Xiangya Hospital of Central South UniversityChangshaChina
  2. 2.National Hepatobiliary and Enteric Surgery Research Center of Ministry of HealthChangshaPeople’s Republic of China
  3. 3.Department of Health ToxicologySchool of Public Health of Central South UniversityChangshaChina

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