Tumor Biology

, Volume 33, Issue 5, pp 1437–1444 | Cite as

Expression of Frat1 correlates with expression of β-catenin and is associated with a poor clinical outcome in human SCC and AC

  • Yong Zhang
  • Yang Han
  • Rui Zheng
  • Juan-Han Yu
  • Yuan Miao
  • Liang Wang
  • En-Hua Wang
Research Article


Overexpression of frequently rearranged in advanced T-cell lymphomas 1 (Frat1) has been reported in several human malignant tumors, but the relationship between Frat1 and β-catenin in lung cancer is still unclear. Our goal was to investigate the correlation between Frat1 and β-catenin in patients with lung cancers. Immunohistochemistry was performed in 110 cases of non-small cell lung cancer (NSCLC) with clinical follow-up. Results showed that both Frat1 and β-catenin were overexpressed in NSCLC. The expression of Frat1 and β-catenin was significantly correlated with tumor differentiation, TNM stage, and lymph node metastasis. Interestingly, the overexpression of β-catenin was positively correlated with the overexpression of Frat1 (correlation coefficient = 0.285; P = 0.003). In addition, overexpression of Frat1 and abnormal expression of β-catenin were found to represent a poor prognosis for the patients. Furthermore, based on the transfection of Frat1 and β-catenin, we found that Frat1 can upregulate the expression of β-catenin in BE1 cells.


Frat1 β-Catenin NSCLC Wnt pathway 



Frequently rearranged in advanced T-cell lymphomas 1


Non-small cell lung cancer


Squamous cell carcinoma


Axis inhibition protein


Frizzled protein


Disheveled protein



All lung tissue samples were obtained from the First Affiliated Hospital of China Medical University. The study was conducted according to the regulations of the institutional review boards at China Medical University (grants 30870977 and 81071905 to En-Hua Wang).

Conflicts of interest

The authors declare that they have no competing financial interests. No part of this article has been published or submitted elsewhere, and there are no financial or other relationships that might lead to a conflict of interest of this article. The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and each author believes that the manuscript represents honest work.


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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2012

Authors and Affiliations

  • Yong Zhang
    • 1
    • 2
  • Yang Han
    • 1
    • 2
  • Rui Zheng
    • 3
  • Juan-Han Yu
    • 1
    • 2
  • Yuan Miao
    • 1
    • 2
  • Liang Wang
    • 1
    • 2
  • En-Hua Wang
    • 1
    • 2
  1. 1.Department of Pathology, The First Affiliated Hospital and College of Basic Medical SciencesChina Medical UniversityShenyangPeople’s Republic of China
  2. 2.Institute of Pathology and PathophysiologyChina Medical UniversityShenyangPeople’s Republic of China
  3. 3.Department of Respiratory Internal MedicineShengjing Hospital, China Medical UniversityShenyangPeople’s Republic of China

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