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Tumor Biology

, Volume 33, Issue 3, pp 661–667 | Cite as

Nuclisome—targeting the tumor cell nucleus

  • Lars Gedda
  • Katarina Edwards
Research Article

Abstract

The Nuclisome concept builds on a novel two-step targeting strategy with the aim to deliver short-range Auger-electron-emitting radionuclides to nuclear DNA of tumor cells. The concept is based on the use of Nuclisome-particles, i.e., tumor-targeted PEG-stabilized liposomes loaded with a unique DNA-intercalating compound that enables specific and effective delivery of radionuclides to DNA. The specific and potent two-step targeting leads to eradication of tumor cells while toxicity to normal organs is reduced to a minimum. Results of in vitro and in vivo studies point towards the Nuclisome concept as a promising strategy for the treatment of small tumor masses and, in particular, for the elimination of spread single cells and micrometastases.

Keywords

Auger Intercalator Liposome Radionuclide DNA 

Notes

Acknowledgments

Financial support from the Swedish Cancer Society, the Swedish Research Council, and Stiftelsen Olle Engkvist Byggmästare is gratefully acknowledged.

Conflicts of interest

None.

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2012

Authors and Affiliations

  1. 1.Department of Radiology, Oncology and Radiation Sciences, Unit of Biomedical Radiation Sciences, Rudbeck LaboratoryUppsala UniversityUppsalaSweden
  2. 2.Department of Physical and Analytical ChemistryUppsala UniversityUppsalaSweden
  3. 3.FRIAS, School of Soft Matter ResearchUniversity of FreiburgFreiburgGermany

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