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Tumor Biology

, Volume 33, Issue 2, pp 455–461 | Cite as

Distribution of mast cells in benign odontogenic tumors

  • Francisco de Assis Caldas Pereira
  • Clarissa Araújo Silva Gurgel
  • Eduardo Antônio Gonçalves Ramos
  • Manuela Torres Andion Vidal
  • Antônio Luiz Barbosa Pinheiro
  • Vladimir Jurisic
  • Caroline Brandi Schlaepfer Sales
  • Patrícia Ramos Cury
  • Jean Nunes dos Santos
Research Article

Abstract

The aim of this study was to investigate the presence of mast cells in a series of odontogenic tumors. Forty-five cases of odontogenic tumors were investigated using immunohistochemistry for mast cell triptase, and differences between groups were statistically evaluated. Mast cells were present in 96% of odontogenic tumors. Mast cells present in solid ameloblastoma were observed in the tumor stroma surrounding more solid and follicular epithelial islands, with or without squamous metaplasia. The odontogenic mixoma showed few mast cells. In odontogenic tumors with a cystic structure, the mast cells were distributed throughout all areas of the lesions, mainly in keratocystic odontogenic tumor. In addition, the total density of mast cells between all odontogenic tumors showed no significant difference (p > 0.05). A greater mast cells distribution was found in keratocystic odontogenic tumor in relation to adenomatoid odontogenic tumor (p < 0.01), and when the unicystic ameloblastoma and keratocistic odontogenic tumor were compared to the odontogenic myxoma (p < 0.05). Syndrome keratocystic odontogenic tumor showed a higher mean of mast cells when compared with the other tumors of the sample. Mast cells values presented by syndrome keratocystic odontogenic tumor were significantly greater than those of the sporadic keratocystic odontogenic tumor that were not associated with the syndrome (p = 0.03). Mast cells are probably one of the major components of the stromal scaffold in odontogenic tumors. We found significant differences of mast cells between syndrome nonsyndrome keratocystic odontogenic tumors, although their distribution did not seem to have any influence on the biologic behavior of benign odontogenic tumors.

Keywords

Mast cell Immunohistochemistry Odontogenic tumors Ameloblastomas 

Notes

Acknowledgements

This study was supported by Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq).

Conflict of interest

None.

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2011

Authors and Affiliations

  • Francisco de Assis Caldas Pereira
    • 1
  • Clarissa Araújo Silva Gurgel
    • 1
  • Eduardo Antônio Gonçalves Ramos
    • 2
  • Manuela Torres Andion Vidal
    • 1
  • Antônio Luiz Barbosa Pinheiro
    • 3
  • Vladimir Jurisic
    • 4
  • Caroline Brandi Schlaepfer Sales
    • 2
  • Patrícia Ramos Cury
    • 5
  • Jean Nunes dos Santos
    • 1
    • 6
  1. 1.Department of Oral Pathology, Laboratory of Surgical Pathology, School of DentistryFederal University of BahiaSalvadorBrazil
  2. 2.Gonçalo Moniz Research CenterOswaldo Cruz FoundationSalvadorBrazil
  3. 3.Center of Biophotonic, School of DentistryFederal University of BahiaSalvadorBrazil
  4. 4.School of MedicineUniversity of KragujevacBelgradeSerbia
  5. 5.Department of Periodontics, School of DentistryFederal University of BahiaSalvadorBrazil
  6. 6.Faculdade de odontologia, Laboratório de Patologia CirúrgicaUniversidade Federal da BahiaSalvadorBrazil

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