Distribution of mast cells in benign odontogenic tumors
- 262 Downloads
The aim of this study was to investigate the presence of mast cells in a series of odontogenic tumors. Forty-five cases of odontogenic tumors were investigated using immunohistochemistry for mast cell triptase, and differences between groups were statistically evaluated. Mast cells were present in 96% of odontogenic tumors. Mast cells present in solid ameloblastoma were observed in the tumor stroma surrounding more solid and follicular epithelial islands, with or without squamous metaplasia. The odontogenic mixoma showed few mast cells. In odontogenic tumors with a cystic structure, the mast cells were distributed throughout all areas of the lesions, mainly in keratocystic odontogenic tumor. In addition, the total density of mast cells between all odontogenic tumors showed no significant difference (p > 0.05). A greater mast cells distribution was found in keratocystic odontogenic tumor in relation to adenomatoid odontogenic tumor (p < 0.01), and when the unicystic ameloblastoma and keratocistic odontogenic tumor were compared to the odontogenic myxoma (p < 0.05). Syndrome keratocystic odontogenic tumor showed a higher mean of mast cells when compared with the other tumors of the sample. Mast cells values presented by syndrome keratocystic odontogenic tumor were significantly greater than those of the sporadic keratocystic odontogenic tumor that were not associated with the syndrome (p = 0.03). Mast cells are probably one of the major components of the stromal scaffold in odontogenic tumors. We found significant differences of mast cells between syndrome nonsyndrome keratocystic odontogenic tumors, although their distribution did not seem to have any influence on the biologic behavior of benign odontogenic tumors.
KeywordsMast cell Immunohistochemistry Odontogenic tumors Ameloblastomas
This study was supported by Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq).
Conflict of interest
- 17.Barnes L, Eveson JW, Reichart P, Sidransky D. World Health Organization of tumours, pathology & genetics, head and neck tumours. Lyon: IARC press; 2005.Google Scholar
- 22.Wayner A, Carter G, Piotrowicz S, Kunick TJ. The function of multiple extracellular matrix receptors in mediating cell adhesion to extracellular matrix: preparation of monoclonal antibodies to the fibronectin receptor that specifically inhibit cell adhesion to fibronectin and react with platelet glycoproteins Ic-IIa. J Cell Biol. 1988;107:1881–91.PubMedCrossRefGoogle Scholar
- 23.Dastuch J, Costa J, Thompson H, Metcalf TD. Mast cell adhesion to fibronectin. Immunology. 1991;73:478–84.Google Scholar
- 36.Ribatti D, Vacca A, Ria R, Marzullo A, Nico B, Filotico R, Roncali L, et al. Neovascularization, expression of fibroblast growth factor-2, and mast cells with tryptase activity increase simultaneously with pathological progression in human malignant melanoma. Eur J Cancer. 2003;39:666–74.PubMedCrossRefGoogle Scholar