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PATHOGENETIC AND DIAGNOSTIC ROLE OF STEROID-LINKED PROTEINS IN BREAST CANCER
N Scvortsova (1), A Kokhanov (1), D Nikulina (1), T Vorobyeva (1), N Abramovich (1)
(1) Medical Academy, Astrakhan, Russia
Aims: To determine SHBG, transcortin, and α2-PAG level changes in breast cancer patient blood.
Methods: Proteins in blood serum were determined by immunochemical methods (ELISA, IDA) in 150 samples of breast cancer patient blood; total samples, donors’ included made 210.
Results:Results of the study showed that in the blood of breast cancer patients the level of proteins charged with estrogen and testosterone transport is increased, and the transcortin level charged with progesterone and corticosteroid transport is decreased. That is, a discrepancy (“shear” phenomenon) was revealed. SHBG level increased and was 1.7 times as high as the mean referential interval and 2-fold its normal level. Transcortin decreased 2.2 times the mean referential interval and half its normal level in...