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Tumor Biology

, Volume 31, Supplement 1, pp 31–33 | Cite as

Biostatistics workshops

Article

BioStat-Workshop-1

STATISTICAL EVALUATION OF A NOVEL MARKER

MW Kattan (1)

(1) Cleveland Clinic, Cleveland, Ohio, USA

Numerous analyses of new markers are published routinely.

Discovery of a new marker may be important for a variety of reasons. For example the new marker might yield insight on a disease process. However, the common application and analysis of a new marker is that of stratifying patients with respect to the outcome. The typical scenario is the collection of a dataset containing the new marker, established markers, and patient outcome.

In this setting the scientist desires from the biostatistician an analysis of the empirical value of the new marker.

While there may be other value in discovery of a particular marker, the central issue here is often prediction of outcome. When a new marker is identified the founder would like others to measure and use it because of the belief that it would be better able to predict patient outcome and, thereby, improve patient counseling...

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© International Society of Oncology and BioMarkers (ISOBM) 2010

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