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Tumor Biology

, Volume 32, Issue 2, pp 259–264 | Cite as

MMP-7 as a prognostic marker in colorectal cancer

  • Selja Koskensalo
  • Johanna Louhimo
  • Stig Nordling
  • Jaana Hagström
  • Caj Haglund
Research Article

Abstract

Matrix metalloproteinase-7 is capable of degrading many extracellular matrix proteins and cellular adhesions. In many malignancies, it is overexpressed, and it plays a role in cancer progression by enhancing tumor invasion and thereby metastatic potential. The purpose of this study was to evaluate the association between MMP-7 tissue expression and prognosis in colorectal cancer. From 623 patients who underwent surgery for colorectal cancer, surgical specimens were collected into tissue array blocks and stained by immunohistochemistry for MMP-7. Specimens from 545 patients were suitable for analysis. In specimens from 105 patients (19.3%), MMP-7 scored as high; in 103 (18.9%), as moderate; and in 134 (24.9%), as mild. In 203 cases (37.2%), immunoreactivity was negative. A significant correlation appeared between MMP-7 immunoexpression and tumor differentiation. High MMP-7 positivity associated with poor prognosis during a 5-year follow-up. During longer follow-up, the differences in survival between groups disappeared. MMP-7 is a potential target for tumor therapy, which should be evaluated in clinical trials.

Keywords

MMP-7 Colorectal cancer Immunohistochemistry Prognosis 

Notes

Acknowledgements

We thank Päivi Peltokangas, Tuire Koski, and Elina Aspiala for technical assistance.

Funding

This study was supported by Finska Läkaresällskapet, Medicinska Understödsföreningen Liv och Hälsa, and the Sigrid Jusélius Foundation.

Ethics approval

The study has been approved by local ethics committee and complies with the Declaration of Helsinki (Dnro HUS 226/E6/06).

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2010

Authors and Affiliations

  • Selja Koskensalo
    • 1
  • Johanna Louhimo
    • 1
  • Stig Nordling
    • 2
  • Jaana Hagström
    • 2
  • Caj Haglund
    • 1
    • 2
  1. 1.Department of SurgeryHelsinki University Central HospitalHelsinkiFinland
  2. 2.Department of PathologyHelsinki University Central HospitalHelsinkiFinland

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